PAQR5 - progestin and adipoQ receptor family member 5 Gene

Homo sapiens

Also known as MPRG

Gene ID: 54852 | Gene type: protein coding

About PAQR5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,298,912-69,407,780 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 10 paralogues. Biased expression in kidney (RPKM 13.9), adrenal (RPKM 5.4) and 9 other tissues.

Summary

Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

PAQR5 Products(2)

mRNA	Protein	Name
NM_001104554.2	NP_001098024.1	membrane progestin receptor gamma
NM_017705.4	NP_060175.3	membrane progestin receptor gamma

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAQR5 Protein Structure

HlyIII

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

membrane progestin receptor gamma

mPR gamma

PAQR5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAQR5	Q9NXK6	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	PAQR5	Q9NXK6	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	PAQR5	Q9NXK6	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	PAQR5	Q9NXK6	IGSF9	Homo sapiens	Q9P2J2-2	Validated Y2H	32296183
Intra	PAQR5	Q9NXK6	IGSF9	Homo sapiens	Q9P2J2-2	Y2H Prey Pooling	32296183
Intra	PAQR5	Q9NXK6	IGSF9	Homo sapiens	Q9P2J2-2	Y2H Array	32296183
Intra	PAQR5	Q9NXK6	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	PAQR5	Q9NXK6	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	PAQR5	Q9NXK6	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	PAQR5	Q9NXK6	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	PAQR5	Q9NXK6	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	PAQR5	Q9NXK6	PHYHIP	Homo sapiens	Q92561	Anti Tag CoIP	33961781
Intra	PAQR5	Q9NXK6	PHYHIP	Homo sapiens	Q92561	Anti Tag CoIP	28514442
Intra	PAQR5	Q9NXK6	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	PAQR5	Q9NXK6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	PAQR5	Q9NXK6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myositis Fibrosa

Interstitial Myositis

Cloacal Exstrophy

Oeis Complex	Omphalocele-Cloacal Exstrophy-Imperforate Anus-Spinal Defect Syndrome
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Compl	Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Complex
Cloacal Exstrophy Sequence	Omphalocele - Cloacal Exstrophy - Imperforate Anus - Spinal Defect
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects	Omphalocele Exstrophy Imperforate Anus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10033	PAQR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PAQR5	VGNC	VGNC:44261
Rattus norvegicus	PAQR5	RGD	RGD:1311259
Felis catus	PAQR5	VGNC	VGNC:64036
Bos taurus	PAQR5	VGNC	VGNC:32577
Mus musculus	PAQR5	MGD	MGI:1921340
Macaca mulatta	PAQR5	VGNC	VGNC:75694

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