PPP1R18 - protein phosphatase 1 regulatory subunit 18 Gene

Homo sapiens

Also known as HKMT1098; KIAA1949

Gene ID: 170954 | Gene type: protein coding

About PPP1R18

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,676,389-30,688,391 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 121 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 31.8), appendix (RPKM 27.5) and 24 other tissues.

Summary

Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the Enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) Cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

PPP1R18 Products(2)

mRNA	Protein	Name
NM_001134870.2	NP_001128342.1	phostensin
NM_133471.4	NP_597728.1	phostensin

PPP1R18 Protein Structure

Phostensin_N

Phostensin

0
100
200
300
400
500
613 a.a.

Protein Preferred Names

Protein Names

phostensin

protein phosphatase 1 F-actin cytoskeleton targeting subunit

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 79

DFNB79	Autosomal Recessive Nonsyndromic Deafness 79
Autosomal Recessive Deafness 79	Deafness, Autosomal Recessive, 79
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 79	Deafness, Autosomal Recessive, Type 79

Schizophrenia 4

SCZD4	Schizophrenia, Susceptibility To, 4
Schizophrenia Susceptibility Locus, Chromosome 22q11-Related	Schizophrenia Susceptibility Locus Chromosome 22-Related
Schizophrenia, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10991	PPP1R18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP1R18	VGNC	VGNC:102489
Macaca mulatta	PPP1R18	VGNC	VGNC:104421
Bos taurus	PPP1R18	VGNC	VGNC:33233
Mus musculus	PPP1R18	MGD	MGI:1923698
Rattus norvegicus	PPP1R18	RGD	RGD:1309543
Canis familiaris	PPP1R18	VGNC	VGNC:57230

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