2. Gene
  3. PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP2CA; PP2Calpha; PP2C-ALPHA

Gene ID: 5494 | Gene type: protein coding

About PPM1A

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,245,750-60,299,087 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This Phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and Apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

PPM1A Products(3)

mRNA Protein Name
NM_021003.5 NP_066283.1 protein phosphatase 1A isoform 1
NM_177951.3 NP_808820.1 protein phosphatase 1A isoform 2
NM_177952.3 NP_808821.2 protein phosphatase 1A isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
16751101 GOA
enables calmodulin-dependent protein phosphatase activity IDA
IDA: Inferred from direct assay
11559703 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10644691 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
10644691 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
10644691 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18930133 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18930133 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16751101 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
11559703 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10644691 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10644691 GOA
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
18930133 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
16751101 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1A Protein Structure

PP2C

PP2C: Protein phosphatase 2C (23 - 284)

PP2C_C

PP2C_C: Protein serine/threonine phosphatase 2C, C-terminal domain (285 - 364)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1A

PPM1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPM1A P35813 EGFR Homo sapiens P00533
Ub Reconstruction
28065597
Intra
PPM1A P35813 IGF1R Homo sapiens P08069
Ub Reconstruction
28065597
Intra
PPM1A P35813 AXIN1 Homo sapiens O15169
Anti Bait CoIP
10644691
Intra
PPM1A P35813 ARRB2 Homo sapiens P32121
Anti Tag CoIP
17620599
Intra
PPM1A P35813 MAPK14 Homo sapiens Q16539
Phosphatase Assay
23560844
Intra
PPM1A P35813 MAPK1 Homo sapiens P28482
Pull Down
23560844
Intra
PPM1A P35813 MAPK1 Homo sapiens P28482
Phosphatase Assay
23560844
Intra
PPM1A P35813 RANBP3 Homo sapiens Q9H6Z4
Anti Bait CoIP
21960005
Intra
PPM1A P35813 RANBP3 Homo sapiens Q9H6Z4
Pull Down
21960005
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPM1A Proteins

Cat. No. Product Name Accession Purity
HY-P71227 PPM1A Protein, Human (His) P35813-1 (G2-W382) ≥95%

Related Diseases

Diseases Alias
Buschke-Ollendorff Syndrome

BOS

Dermatoosteopoikilosis

Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis

Osteopathia Condensans Disseminata

Dermatofibrosis Lenticularis Disseminata

Disseminated Dermatofibrosis With Osteopoikilosis

Dermatofibrosis, Disseminated, With Osteopoikilosis

Osteopoikilosis With Or Without Melorheostosis

Dermatofibrosis, Disseminated With Osteopoikilosis

Dermatofibrosis Disseminata Lenticularis

Isolated Osteopoikilosis

Osteopoikilosis, Isolated
Osteopoikilosis

Osteopathia Condensans Disseminata

Spotted Bones

Dermatofibrosis Lenticularis Disseminata
Melorheostosis

Candle Wax Disease

Flowing Hyperostosis

Hyperostosis, Monomelic

Leri Syndrome

Leri'S Disease

Melorheostoses

Melorheostosis Of Leri

Melorheostosis, Isolated

Periostitis

Monomelic

Rheostosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-164220 PPM1A-IN-1 Inhibitor ≥95.0% Unkown
HY-163782 SMIP-031 / Unkown
HY-RS10960 PPM1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPM1A MGD MGI:99878
Canis familiaris PPM1A VGNC VGNC:44862
Felis catus PPM1A VGNC VGNC:68992
Macaca mulatta PPM1A VGNC VGNC:84422
Rattus norvegicus PPM1A RGD RGD:3373
Others PPM1A NCBI