2. Gene
  3. PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP2CA; PP2Calpha; PP2C-ALPHA

Gene ID: 5494 | Gene type: protein coding

About PPM1A

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,245,750-60,299,087 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This Phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and Apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

PPM1A Products(3)

mRNA Protein Name
NM_021003.5 NP_066283.1 protein phosphatase 1A isoform 1
NM_177951.3 NP_808820.1 protein phosphatase 1A isoform 2
NM_177952.3 NP_808821.2 protein phosphatase 1A isoform 3

PPM1A Protein Structure

PP2C

PP2C: Protein phosphatase 2C (23 - 284)

PP2C_C

PP2C_C: Protein serine/threonine phosphatase 2C, C-terminal domain (285 - 364)

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  • 382 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1A

Recombinant PPM1A Proteins

Cat. No. Product Name Accession Purity
HY-P71227 PPM1A Protein, Human (His) P35813-1 (G2-W382) ≥95%

Related Diseases

Diseases Alias
Buschke-Ollendorff Syndrome

BOS

Dermatoosteopoikilosis

Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis

Osteopathia Condensans Disseminata

Dermatofibrosis Lenticularis Disseminata

Disseminated Dermatofibrosis With Osteopoikilosis

Dermatofibrosis, Disseminated, With Osteopoikilosis

Osteopoikilosis With Or Without Melorheostosis

Dermatofibrosis, Disseminated With Osteopoikilosis

Dermatofibrosis Disseminata Lenticularis

Isolated Osteopoikilosis

Osteopoikilosis, Isolated
Osteopoikilosis

Osteopathia Condensans Disseminata

Spotted Bones

Dermatofibrosis Lenticularis Disseminata
Melorheostosis

Candle Wax Disease

Flowing Hyperostosis

Hyperostosis, Monomelic

Leri Syndrome

Leri'S Disease

Melorheostoses

Melorheostosis Of Leri

Melorheostosis, Isolated

Periostitis

Monomelic

Rheostosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-164220 PPM1A-IN-1 Inhibitor / Unkown
HY-163782 SMIP-031 / Unkown
HY-RS10960 PPM1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPM1A MGD MGI:99878
Canis familiaris PPM1A VGNC VGNC:44862
Felis catus PPM1A VGNC VGNC:68992
Macaca mulatta PPM1A VGNC VGNC:84422
Rattus norvegicus PPM1A RGD RGD:3373
Others PPM1A NCBI