PPM1B - protein phosphatase, Mg2+/Mn2+ dependent 1B Gene

Homo sapiens

Also known as PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X

Gene ID: 5495 | Gene type: protein coding

About PPM1B

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:44,168,875-44,246,928 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 9.6), brain (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

PPM1B Products(4)

mRNA	Protein	Name
NM_001033557.3	NP_001028729.1	protein phosphatase 1B isoform 5
NM_002706.6	NP_002697.1	protein phosphatase 1B isoform 1
NM_177968.4	NP_808907.1	protein phosphatase 1B isoform 2
NM_177969.4	NP_808908.1	protein phosphatase 1B isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16872604	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	20801214	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18930133	GOA
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	22750291	GOA
involved in negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22750291	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18930133	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	20801214	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	18930133	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1B Protein Structure

PP2C

PP2C_C

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1B

protein phosphatase 2C-like protein

PPM1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPM1B	O75688	ARRB2	Homo sapiens	P32121	PLA	25241761
Intra	PPM1B	O75688	ARRB1	Homo sapiens	P49407	Anti Tag CoIP	17620599
Intra	PPM1B	O75688	ISG15	Homo sapiens	P05161	Anti Tag CoIP	16872604
Intra	PPM1B	O75688	ISG15	Homo sapiens	P05161	Anti Bait CoIP	16872604

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159521	HN252		98.54%	Unkown
HY-RS10961	PPM1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPM1B	VGNC	VGNC:68993
Bos taurus	PPM1B	VGNC	VGNC:33209
Mus musculus	PPM1B	MGD	MGI:101841
Macaca mulatta	PPM1B	VGNC	VGNC:76241
Rattus norvegicus	PPM1B	RGD	RGD:3374
Canis familiaris	PPM1B	VGNC	VGNC:44863

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