PPM1G - protein phosphatase, Mg2+/Mn2+ dependent 1G Gene

Homo sapiens

Also known as PP2CG; PPP2CG; PP2CGAMMA

Gene ID: 5496 | Gene type: protein coding

About PPM1G

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,381,199-27,409,591 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 16 paralogues. Broad expression in testis (RPKM 133.0), lymph node (RPKM 28.8) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this Phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

PPM1G Products(1)

mRNA	Protein	Name
NM_177983.3	NP_817092.1	protein phosphatase 1G

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17572683	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	20801214	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	20801214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1G Protein Structure

PP2C

0
100
200
300
400
500
546 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1G

PP2C-gamma

PPM1G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPM1G	O15355	CHEK2	Homo sapiens	O96017	Anti Tag CoIP	34591612
Intra	PPM1G	O15355	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	28330616
Intra	PPM1G	O15355	XRCC6	Homo sapiens	P12956	BioID	28330616
Intra	PPM1G	O15355	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	35271311
Intra	PPM1G	O15355	XRCC6	Homo sapiens	P12956	Pull Down	28330616
Intra	PPM1G	O15355	YBX1	Homo sapiens	P67809	Far-WB	17572683
Intra	PPM1G	O15355	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	28330616
Intra	PPM1G	O15355	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	35271311
Intra	PPM1G	O15355	XRCC5	Homo sapiens	P13010	BioID	28330616
Intra	PPM1G	O15355	XRCC5	Homo sapiens	P13010	Pull Down	28330616
Intra	PPM1G	O15355	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPM1G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71022	PP1MG Protein, Human (His)	O15355 (M317-D546)	≥95%

Related Diseases

Diseases

Alias

Conduct Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10965	PPM1G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPM1G	VGNC	VGNC:76243
Canis familiaris	PPM1G	VGNC	VGNC:44867
Mus musculus	PPM1G	MGD	MGI:106065
Bos taurus	PPM1G	VGNC	VGNC:33213
Rattus norvegicus	PPM1G	RGD	RGD:628676
Felis catus	PPM1G	VGNC	VGNC:68995
Others	PPM1G	NCBI

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