YBX1 - Y-box binding protein 1 Gene

Homo sapiens

Also known as YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1

Gene ID: 4904 | Gene type: protein coding

About YBX1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,682,418-42,703,805 (from NCBI)

This gene has 4 transcripts (splice variants), 343 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 220.6), fat (RPKM 121.2) and 25 other tissues.

Summary

This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in MicroRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with Cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

YBX1 Products(2)

mRNA	Protein	Name
NM_004559.5	NP_004550.2	Y-box-binding protein 1
NM_004559.5	NP_004550.2	Y-box-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C5-methylcytidine-containing RNA reader activity	IDA IDA: Inferred from direct assay	31358969	GOA
enables GTPase binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	19561594	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	27559612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12674497	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	19029303	GOA
involved in CRD-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	19029303	GOA
involved in RNA transport	IMP IMP: Inferred from mutant phenotype	29073095	GOA
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	31358969	GOA
involved in miRNA transport	IDA IDA: Inferred from direct assay	27559612	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	19029303	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	19029303	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18809583	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24965446	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18809583	GOA
involved in tRNA transport	IMP IMP: Inferred from mutant phenotype	29073095	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CRD-mediated mRNA stability complex	IDA IDA: Inferred from direct assay	19029303	GOA
part of CRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	19029303	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24965446	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	18335541	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19029303	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	27559612	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YBX1 Protein Structure

CSD

0
100
200
300
324 a.a.

Protein Preferred Names

Protein Names

Y-box-binding protein 1

CCAAT-binding transcription factor I subunit A

YBX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	YBX1	P67809	PITX2	Homo sapiens	Q99697	Anti Bait CoIP	19174163
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Confocal	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	23986595
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	35271311
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	TAP	22118625
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Bait CoIP	25497084
Intra	YBX1	P67809	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	33961781
Intra	YBX1	P67809	LSM3	Homo sapiens	P62310	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	23986595
Intra	YBX1	P67809	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	21849455
Intra	YBX1	P67809	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	16797541
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	YBX1	P67809	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Pull Down	12674497
Intra	YBX1	P67809	HNRNPD	Homo sapiens	Q14103-4	Y2H	12674497
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	TAP	24981860
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Anti Tag CoIP	16797541
Intra	YBX1	P67809	FBXO33	Homo sapiens	Q7Z6M2	Pull Down	16797541
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	IF	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Anti Bait CoIP	24965446
Cross	YBX1	P67809	P19712-PRO_0000038050	Classical swine fever virus	P19712-PRO_0000038050	Pull Down	24965446
Cross	YBX1	P67809	CTCF	Gallus gallus	Q08705	Pull Down	15229244

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Liposarcoma

Lipomatous Cancer

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16252	Ybx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15916	YBX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	YBX1	RGD	RGD:61843
Bos taurus	YBX1	VGNC	VGNC:50233
Mus musculus	YBX1	MGD	MGI:99146
Macaca mulatta	YBX1	VGNC	VGNC:100189
Felis catus	YBX1	VGNC	VGNC:80405
Others	YBX1	NCBI

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