TIPIN - TIMELESS interacting protein Gene

Homo sapiens

Gene ID: 54962 | Gene type: protein coding

About TIPIN

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,336,191-66,386,717 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.8) and 24 other tissues.

Summary

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TIPIN Products(9)

mRNA	Protein	Name
NM_001289986.2	NP_001276915.1	TIMELESS-interacting protein isoform 2
NM_001398281.1	NP_001385210.1	TIMELESS-interacting protein isoform 1
NM_001398282.1	NP_001385211.1	TIMELESS-interacting protein isoform 1
NM_001398283.1	NP_001385212.1	TIMELESS-interacting protein isoform 1
NM_001398284.1	NP_001385213.1	TIMELESS-interacting protein isoform 1
NM_001398285.1	NP_001385214.1	TIMELESS-interacting protein isoform 2
NM_001398286.1	NP_001385215.1	TIMELESS-interacting protein isoform 2
NM_001398287.1	NP_001385216.1	TIMELESS-interacting protein isoform 2
NM_017858.3	NP_060328.3	TIMELESS-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17102137	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17102137	GOA
involved in cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	17102137	GOA
involved in mitotic intra-S DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17102137	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17102137	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	17102137	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17102137	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIPIN Protein Structure

Swi3

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

TIMELESS-interacting protein

CSM3 homolog

TIPIN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIPIN	Q9BVW5	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	TIPIN	Q9BVW5	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	TIPIN	Q9BVW5	TIMELESS	Homo sapiens	Q9UNS1	Chromatography	32705708
Intra	TIPIN	Q9BVW5	TIMELESS	Homo sapiens	Q9UNS1	Anti Bait CoIP	17116885
Intra	TIPIN	Q9BVW5	TIMELESS	Homo sapiens	Q9UNS1	Anti Tag CoIP	33961781
Intra	TIPIN	Q9BVW5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	TIPIN	Q9BVW5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	TIPIN	Q9BVW5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	TIPIN	Q9BVW5	RPA2	Homo sapiens	P15927	ITC	24910198
Intra	TIPIN	Q9BVW5	RPA2	Homo sapiens	P15927	NMR	24910198
Intra	TIPIN	Q9BVW5	TEX11	Homo sapiens	Q8IYF3	Validated Y2H	25416956
Intra	TIPIN	Q9BVW5	TEX11	Homo sapiens	Q8IYF3	Y2H Prey Pooling	25416956
Intra	TIPIN	Q9BVW5	TEX11	Homo sapiens	Q8IYF3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14549	TIPIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIPIN	VGNC	VGNC:47382
Mus musculus	TIPIN	MGD	MGI:1921571
Macaca mulatta	TIPIN	VGNC	VGNC:79873
Bos taurus	TIPIN	VGNC	VGNC:35877
Rattus norvegicus	TIPIN	RGD	RGD:1564084
Felis catus	TIPIN	VGNC	VGNC:80821

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