ENOX1 - ecto-NOX disulfide-thiol exchanger 1 Gene

Homo sapiens

Also known as CNOX; PIG38; cCNOX; bA64J21.1

Gene ID: 55068 | Gene type: protein coding

About ENOX1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,213,130-43,786,972 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.9), brain (RPKM 1.3) and 19 other tissues.

Summary

The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. [provided by RefSeq, Dec 2016]

ENOX1 Products(12)

mRNA	Protein	Name
NM_001127615.3	NP_001121087.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001242863.3	NP_001229792.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347963.2	NP_001334892.1	ecto-NOX disulfide-thiol exchanger 1 isoform a
NM_001347964.2	NP_001334893.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347965.2	NP_001334894.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347966.2	NP_001334895.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347967.2	NP_001334896.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347968.2	NP_001334897.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347969.2	NP_001334898.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347970.2	NP_001334899.1	ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_001347971.2	NP_001334900.1	ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_017993.5	NP_060463.2	ecto-NOX disulfide-thiol exchanger 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADH dehydrogenase activity	IDA IDA: Inferred from direct assay	19055324	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	19055324	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOX1 Protein Structure

RRM_1

0
100
200
300
400
500
600
643 a.a.

Protein Preferred Names

Protein Names

ecto-NOX disulfide-thiol exchanger 1

candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase

Related Diseases

Diseases

Alias

Hypocalcemia, Autosomal Dominant 2

Autosomal Dominant Hypocalcemia 2	HYPOC2
Hypocalcemia, Autosomal Dominant, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04384	ENOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ENOX1	VGNC	VGNC:40371
Mus musculus	ENOX1	MGD	MGI:2444896
Bos taurus	ENOX1	VGNC	VGNC:28502
Macaca mulatta	ENOX1	VGNC	VGNC:72110
Felis catus	ENOX1	VGNC	VGNC:61869
Rattus norvegicus	ENOX1	RGD	RGD:1306118

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