SLFN12 - schlafen family member 12 Gene

Homo sapiens

Also known as SLFN3

Gene ID: 55106 | Gene type: protein coding

About SLFN12

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,410,922-35,433,174 (from NCBI)

This gene has 8 transcripts (splice variants), 101 orthologues and 6 paralogues. Ubiquitous expression in spleen (RPKM 3.5), urinary bladder (RPKM 3.0) and 24 other tissues.

Summary

Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]

SLFN12 Products(2)

mRNA	Protein	Name
NM_001289009.2	NP_001275938.1	ribonuclease SLFN12
NM_018042.5	NP_060512.3	ribonuclease SLFN12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA nuclease activity	IDA IDA: Inferred from direct assay	34272366	GOA
enables RNA nuclease activity	IMP IMP: Inferred from mutant phenotype	35104454	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31420216	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	31420216	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	31420216	GOA
involved in rRNA catabolic process	IDA IDA: Inferred from direct assay	34272366	GOA
involved in rRNA catabolic process	IMP IMP: Inferred from mutant phenotype	35104454	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	35104454	GOA
located in nucleus	IDA IDA: Inferred from direct assay	35104454	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN12 Protein Structure

AlbA_2

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

ribonuclease SLFN12

schlafen family member 12

SLFN12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLFN12	Q8IYM2	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	SLFN12	Q8IYM2	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	SLFN12	Q8IYM2	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	SLFN12	Q8IYM2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SLFN12	Q8IYM2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SLFN12	Q8IYM2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SLFN12	Q8IYM2	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	SLFN12	Q8IYM2	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	SLFN12	Q8IYM2	LPL	Homo sapiens	P06858	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 20

Platelet-Type Bleeding Disorder 20	BDPLT20
Autosomal Dominant Thrombocytopenia With Platelet Secretion Defect

Monkeypox

Monkeypox Virus Infections

Progesterone-Receptor Positive Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145924	BAY 2666605	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W028690	DNMDP	Inhibitor	98.95%	Unkown
HY-122751	(R)-DNMDP	Inhibitor	99.59%	Unkown
HY-162730	OPB-171775	Inhibitor	99.80%	Unkown
HY-153802	Antitumor agent-100	Inducer	/	Unkown
HY-153802A	Antitumor agent-100 hydrochloride	Inducer	/	Unkown
HY-N10149	Nauclefine		/	Unkown
HY-RS13364	SLFN12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13365	SLFN12L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLFN12	RGD	RGD:620455

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