CRTAC1 - cartilage acidic protein 1 Gene

Homo sapiens

Also known as ASPIC; CEP68; LOTUS; ASPIC1; CEP-68

Gene ID: 55118 | Gene type: protein coding

About CRTAC1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:97,865,000-98,030,621 (from NCBI)

This gene has 6 transcripts (splice variants) and 257 orthologues. Biased expression in lung (RPKM 23.3), brain (RPKM 10.1) and 5 other tissues.

Summary

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

CRTAC1 Products(2)

mRNA	Protein	Name
NM_001206528.3	NP_001193457.1	cartilage acidic protein 1 isoform B precursor
NM_018058.7	NP_060528.3	cartilage acidic protein 1 isoform A precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTAC1 Protein Structure

VCBS

UnbV_ASPIC

EGF_CA

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

cartilage acidic protein 1

acidic secreted protein in cartilage

CRTAC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRTAC1	Q9NQ79	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	25416956
Intra	CRTAC1	Q9NQ79	MORN4	Homo sapiens	Q8NDC4	Y2H Prey Pooling	25416956
Intra	CRTAC1	Q9NQ79	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	CRTAC1	Q9NQ79	MAPRE2	Homo sapiens	Q15555	Anti Tag CoIP	33961781
Intra	CRTAC1	Q9NQ79	MAPRE2	Homo sapiens	Q15555	Y2H Array	31515488
Intra	CRTAC1	Q9NQ79	MAPRE2	Homo sapiens	Q15555	Validated Y2H	25416956
Intra	CRTAC1	Q9NQ79	MAPRE2	Homo sapiens	Q15555	Y2H Array	25416956
Intra	CRTAC1	Q9NQ79	AQP1	Homo sapiens	P29972	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurofibromatosis

Neurofibromatoses	Acoustic Neurofibromatosis
Central Neurofibromatosis	Peripheral Neurofibromatosis
Recklinghausen'S Neurofibromatosis	Von Reklinghausen Disease
Neurofibromatosis Type 1

Soft Tissue Chondroma

Extraskeletal Chondroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03197	CRTAC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CRTAC1	VGNC	VGNC:71408
Mus musculus	CRTAC1	MGD	MGI:1920082
Felis catus	CRTAC1	VGNC	VGNC:61189
Rattus norvegicus	CRTAC1	RGD	RGD:621085
Canis familiaris	CRTAC1	VGNC	VGNC:39629
Bos taurus	CRTAC1	VGNC	VGNC:27725

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