PPP2R2A - protein phosphatase 2 regulatory subunit Balpha Gene

Homo sapiens

Also known as B55A; PR52A; PR55A; B55ALPHA; PR55alpha

Gene ID: 5520 | Gene type: protein coding

About PPP2R2A

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,291,508-26,372,680 (from NCBI)

This gene has 28 transcripts (splice variants), 141 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2 regulatory subunit B family. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R2A Products(2)

mRNA	Protein	Name
NM_001177591.2	NP_001171062.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2
NM_002717.4	NP_002708.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9847399	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	1849734	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	1849734	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	33108758	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	1849734	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

protein phosphatase 2, regulatory subunit B, alpha

PPP2R2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Validated Y2H	32814053
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Array	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Array	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Validated Y2H	32814053
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	20711181
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	BioID	28330616
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	28330616
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	BioID	28330616
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Pull Down	28330616
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	26496610
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Validated Y2H	32814053
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Array	32814053
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Anti Bait CoIP	34731788
Intra	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Confocal	34731788

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11011	PPP2R2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP2R2A	VGNC	VGNC:33255
Mus musculus	PPP2R2A	MGD	MGI:1919228
Macaca mulatta	PPP2R2A	VGNC	VGNC:84103
Canis familiaris	PPP2R2A	VGNC	VGNC:44907
Felis catus	PPP2R2A	VGNC	VGNC:69011
Rattus norvegicus	PPP2R2A	RGD	RGD:620919

Name
Email *

	Sorry, but the email address you supplied was invalid.