2. Gene
  3. PACC1 - proton activated chloride channel 1 Gene

PACC1 - proton activated chloride channel 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PAC; ASOR; hPAC; PAORAC; C1orf75; TMEM206; hTMEM206

Gene ID: 55248 | Gene type: protein coding

About PACC1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,363,928-212,414,886 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Broad expression in brain (RPKM 7.4), kidney (RPKM 4.2) and 23 other tissues.

Summary

Enables pH-gated Chloride Channel activity. Involved in chloride transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PACC1 Products(5)

mRNA Protein Name
NM_001198862.2 NP_001185791.1 proton-activated chloride channel isoform 1
NM_001377478.1 NP_001364407.1 proton-activated chloride channel isoform 3
NM_001377479.1 NP_001364408.1 proton-activated chloride channel isoform 4
NM_001377480.1 NP_001364409.1 proton-activated chloride channel isoform 5
NM_018252.3 NP_060722.2 proton-activated chloride channel isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables pH-gated chloride channel activity IDA
IDA: Inferred from direct assay
31023925 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chloride transport IDA
IDA: Inferred from direct assay
31023925 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
31023925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACC1 Protein Structure

TMEM206

TMEM206: TMEM206 protein family (54 - 350)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

proton-activated chloride channel

acid-sensitive outwardly rectifying channel

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09953 PACC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PACC1 VGNC VGNC:36028
Felis catus PACC1 VGNC VGNC:64018
Mus musculus PACC1 MGD MGI:1914200
Macaca mulatta PACC1 VGNC VGNC:75678
Rattus norvegicus PACC1 RGD RGD:1359339
Canis familiaris PACC1 VGNC VGNC:47525