1. Gene
  2. PLLP - plasmolipin Gene

PLLP - plasmolipin Gene

Homo sapiens

Also known as PMLP; TM4SF11

Gene ID: 51090 | Gene type: protein coding

About PLLP

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:57,256,097-57,284,672 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 14 paralogues. Broad expression in brain (RPKM 41.3), stomach (RPKM 28.7) and 17 other tissues.

Summary

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in compact myelin and membrane raft. Predicted to be integral component of membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PLLP Products(1)

mRNA Protein Name
NM_015993.3 NP_057077.1 plasmolipin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
26002055 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in myelin sheath IDA
IDA: Inferred from direct assay
26002055 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26002055 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLLP Protein Structure

MARVEL

MARVEL: Membrane-associating domain (32 - 160)

  • 0
  • 100
  • 182 a.a.
Protein Preferred Names Protein Names

plasmolipin

plasma membrane proteolipid (plasmolipin)

PLLP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PLLP Q9Y342 MS4A12 Homo sapiens Q9NXJ0
Y2H Array
32296183
Intra PLLP Q9Y342 MS4A12 Homo sapiens Q9NXJ0
Y2H Prey Pooling
25416956
Intra PLLP Q9Y342 MS4A12 Homo sapiens Q9NXJ0
Validated Y2H
25416956
Intra PLLP Q9Y342 MS4A12 Homo sapiens Q9NXJ0
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra PLLP Q9Y342 TMEM174 Homo sapiens Q8WUU8
Y2H Array
32296183
Intra PLLP Q9Y342 TMEM174 Homo sapiens Q8WUU8
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra PLLP Q9Y342 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra PLLP Q9Y342 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra PLLP Q9Y342 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra PLLP Q9Y342 CLDN14 Homo sapiens O95500
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 CLDN14 Homo sapiens O95500
Y2H Array
32296183
Intra PLLP Q9Y342 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra PLLP Q9Y342 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra PLLP Q9Y342 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra PLLP Q9Y342 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra PLLP Q9Y342 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra PLLP Q9Y342 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 CLEC12B Homo sapiens Q2HXU8-2
Y2H Array
32296183
Intra PLLP Q9Y342 CLEC12B Homo sapiens Q2HXU8-2
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra PLLP Q9Y342 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra PLLP Q9Y342 CD164L2 Homo sapiens Q6UWJ8-2
Y2H Array
32296183
Intra PLLP Q9Y342 CD164L2 Homo sapiens Q6UWJ8-2
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra PLLP Q9Y342 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra PLLP Q9Y342 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra PLLP Q9Y342 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra PLLP Q9Y342 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 SYPL2 Homo sapiens Q5VXT5-2
Y2H Array
32296183
Intra PLLP Q9Y342 SYPL2 Homo sapiens Q5VXT5-2
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra PLLP Q9Y342 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra PLLP Q9Y342 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 RNF122 Homo sapiens Q9H9V4
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 RNF122 Homo sapiens Q9H9V4
Y2H Array
32296183
Intra PLLP Q9Y342 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra PLLP Q9Y342 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra PLLP Q9Y342 CYSRT1 Homo sapiens A8MQ03
MAPPIT
32296183
Intra PLLP Q9Y342 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra PLLP Q9Y342 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra PLLP Q9Y342 TIGIT Homo sapiens Q495A1
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TIGIT Homo sapiens Q495A1
Y2H Array
32296183
Intra PLLP Q9Y342 PACC1 Homo sapiens Q9H813
Y2H Array
32296183
Intra PLLP Q9Y342 PACC1 Homo sapiens Q9H813
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra PLLP Q9Y342 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
25416956
Intra PLLP Q9Y342 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
25416956
Intra PLLP Q9Y342 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
25416956
Intra PLLP Q9Y342 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra PLLP Q9Y342 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra PLLP Q9Y342 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Usher Syndrome, Type Iiia

Usher Syndrome Type 3

Ush3

Usher Syndrome Type 3a

USH3A

Usher Syndrome, Type Iii

Usher Syndrome, Type 3

Usher Syndrome, Type 3a

Usher Syndrome Type Iiia

Usher Syndrome 3a

Usher'S Syndrome Type 3

Usher Syndrome Iii

Usher Syndrome Type Iii

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4

Charcot-Marie-Tooth Disease Type 4e

Hereditary Motor And Sensory Neuropathy

Cmt4e

CHN1

Hypomyelinating Neuropathy, Congenital, 1

Charcot-Marie-Tooth Neuropathy Type 4e

Neuropathy, Congenital Hypomyelinating, 1

Ar-Cmt1

Autosomal Recessive Demyelinating Charcot-Marie-Tooth

Cmt4

Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

Hypomyelination, Severe Congenital

Charcot-Marie-Tooth Disease, Type 4e

Charcot-Marie-Tooth Neuropathy, Type 4e

Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

Autosomal Recessive Congenital Hypomyelinating Neuropathy

Congenital Amyelinating Neuropathy

Congenital Hypomyelinating Neuropathy Autosomal Recessive

Neuropathy, Congenital Hypomyelinating Or Amyelinating

Severe Congenital Hypomyelination

Hereditary Sensory Motor Neuropathy

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

Neuropathy, Hypomyelinating, Congenital, Type 1

Neuropathy, Motor And Sensory, Hereditary

Congenital Hypomyelinating Neuropathy

Hereditary Motor And Sensory Neuropathies

Hereditary Sensorimotor Neuropathy

Hmsn - [Hereditary Motor And Sensory Neuropathy]

Hsmn - [Hereditary Sensory And Motor Neuropathy]

Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PLLP VGNC VGNC:33037
Canis familiaris PLLP VGNC VGNC:44699
Rattus norvegicus PLLP RGD RGD:621478
Mus musculus PLLP MGD MGI:1915051
Macaca mulatta PLLP VGNC VGNC:99579