MRGBP - MRG domain binding protein Gene

Homo sapiens

Also known as Eaf7; URCC4; MRG15BP; C20orf20

Gene ID: 55257 | Gene type: protein coding

About MRGBP

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,796,473-62,801,729 (from NCBI)

This gene has 1 transcript (splice variant) and 195 orthologues. Broad expression in testis (RPKM 23.2), ovary (RPKM 4.6) and 24 other tissues.

Summary

Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MRGBP Products(1)

mRNA	Protein	Name
NM_018270.6	NP_060740.1	MRG/MORF4L-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12963728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	27153538	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRGBP Protein Structure

Eaf7

0
100
204 a.a.

Protein Preferred Names

Protein Names

MRG/MORF4L-binding protein

MRG-binding protein

MRGBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRGBP	Q9NV56	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	MRGBP	Q9NV56	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8-2	Anti Tag CoIP	28514442
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	25416956
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Array	32296183
Intra	MRGBP	Q9NV56	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	MRGBP	Q9NV56	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	MRGBP	Q9NV56	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	MRGBP	Q9NV56	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	MRGBP	Q9NV56	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	ANP32E	Homo sapiens	Q9BTT0	Pull Down	24463511
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Anti Tag CoIP	15647280
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Anti Tag CoIP	12963728
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Anti Bait CoIP	16230350
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Anti Tag CoIP	33961781
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
Intra	MRGBP	Q9NV56	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	12963728
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	28514442
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Anti Bait CoIP	16230350
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	33961781
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Y2H Array	32296183
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	32296183
Intra	MRGBP	Q9NV56	MORF4L2	Homo sapiens	Q15014	Anti Tag CoIP	15647280
Intra	MRGBP	Q9NV56	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	MRGBP	Q9NV56	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 5

MRD5	Autosomal Dominant Non-Syndromic Intellectual Disability 5
Intellectual Disability, Autosomal Dominant 5	Mental Retardation, Autosomal Dominant 5
Autosomal Dominant Intellectual Developmental Disorder 5	Syngap1-Related Non-Syndromic Intellectual Disability
Autosomal Dominant Intellectual Disability 5	Syngap1 Syndrome
Syngap1-Related Nsid	Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08646	MRGBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MRGBP	MGD	MGI:1920497
Canis familiaris	MRGBP	VGNC	VGNC:54654
Felis catus	MRGBP	VGNC	VGNC:81122
Rattus norvegicus	MRGBP	RGD	RGD:1308612
Macaca mulatta	MRGBP	VGNC	VGNC:95363
Bos taurus	MRGBP	VGNC	VGNC:31602

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