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  3. MORF4L1 - mortality factor 4 like 1 Gene

MORF4L1 - mortality factor 4 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15

Gene ID: 10933 | Gene type: protein coding

About MORF4L1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,872,890-78,898,139 (from NCBI)

This gene has 23 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 192.5), brain (RPKM 119.7) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 Histone Acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

MORF4L1 Products(5)

mRNA Protein Name
NM_001265603.2 NP_001252532.1 mortality factor 4-like protein 1 isoform 3
NM_001265604.2 NP_001252533.1 mortality factor 4-like protein 1 isoform 3
NM_001265605.2 NP_001252534.1 mortality factor 4-like protein 1 isoform 3
NM_006791.4 NP_006782.1 mortality factor 4-like protein 1 isoform 1
NM_206839.3 NP_996670.1 mortality factor 4-like protein 1 isoform 2

MORF4L1 Protein Structure

Tudor-knot

Tudor-knot: RNA binding activity-knot of a chromodomain (12 - 51)

MRG

MRG: MRG (176 - 350)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

mortality factor 4-like protein 1

Esa1p-associated factor 3 homolog

Related Diseases

Diseases Alias
Paraneoplastic Cerebellar Degeneration

Pcd

Paraneoplastic Cerebellar Ataxia

Rapidely Progressive Cerebellar Syndrome

Subacute Cerebellar Degeneration
Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome

WHS

Chromosome 4p16.3 Deletion Syndrome

Wittwer Syndrome

4p- Syndrome

Pitt Syndrome

4p Deletion Syndrome

Distal Deletion 4p

Distal Monosomy 4p

Telomeric Deletion 4p

Prds

4p Syndrome

Chromosome 4p Syndrome

Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

Wolf Syndrome

Chromosome 4p Deletion Syndrome

Chromosome 4p Monosomy

Del Syndrome

Monosomy 4p

Partial Monosomy 4p

Chromosome 4 Short Arm Deletion
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08593 MORF4L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MORF4L1 VGNC VGNC:56001
Rattus norvegicus MORF4L1 RGD RGD:1307938
Felis catus MORF4L1 VGNC VGNC:97512
Mus musculus MORF4L1 MGD MGI:1096551
Macaca mulatta MORF4L1 VGNC VGNC:84396