PPP2R5C - protein phosphatase 2 regulatory subunit B'gamma Gene

Homo sapiens

Also known as B56G; PR61G; B56gamma

Gene ID: 5527 | Gene type: protein coding

About PPP2R5C

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:101,760,573-101,927,992 (from NCBI)

This gene has 33 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R5C Products(10)

mRNA	Protein	Name
NM_001161725.2	NP_001155197.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e
NM_001161726.2	NP_001155198.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f
NM_001352912.1	NP_001339841.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b
NM_001352913.2	NP_001339842.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g
NM_001352914.2	NP_001339843.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h
NM_001352915.2	NP_001339844.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j
NM_001352916.2	NP_001339845.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i
NM_002719.4	NP_002710.2	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a
NM_178586.3	NP_848701.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b
NM_178587.3	NP_848702.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

PPP2R5C Protein Structure

B56

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

B' alpha regulatory subunit

PPP2R5C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R5C	Q13362	PPP2R1A	Homo sapiens	P30153	Anti Bait CoIP	21460856
Intra	PPP2R5C	Q13362	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	33961781
Intra	PPP2R5C	Q13362	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	21460856
Intra	PPP2R5C	Q13362	TP53	Homo sapiens	P04637	Anti Bait CoIP	21460856
Intra	PPP2R5C	Q13362	TP53	Homo sapiens	P04637	PLA	25241761
Intra	PPP2R5C	Q13362	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	21460856
Intra	PPP2R5C	Q13362	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	21460856
Intra	PPP2R5C	Q13362	PPP2CA	Homo sapiens	P67775	CoIP	1328865
Intra	PPP2R5C	Q13362	PPP2CA	Homo sapiens	P67775	Anti Bait CoIP	21460856

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11020	PPP2R5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP2R5C	VGNC	VGNC:33262
Mus musculus	PPP2R5C	MGD	MGI:1349475
Canis familiaris	PPP2R5C	VGNC	VGNC:44915
Rattus norvegicus	PPP2R5C	RGD	RGD:1585097
Felis catus	PPP2R5C	VGNC	VGNC:69017

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