HAUS7 - HAUS augmin like complex subunit 7 Gene

Homo sapiens

Also known as UIP1; UCHL5IP

Gene ID: 55559 | Gene type: protein coding

About HAUS7

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,447,668-153,495,465 (from NCBI)

This gene has 10 transcripts (splice variants) and 163 orthologues. Ubiquitous expression in skin (RPKM 11.4), spleen (RPKM 5.8) and 24 other tissues.

Summary

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

HAUS7 Products(3)

mRNA	Protein	Name
NM_001385481.1	NP_001372410.1	HAUS augmin-like complex subunit 7 isoform 2
NM_001385482.1	NP_001372411.1	HAUS augmin-like complex subunit 7 isoform 1
NM_001385483.1	NP_001372412.1	HAUS augmin-like complex subunit 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	11163772	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

HAUS augmin-like complex subunit 7

26S proteasome-associated UCH37-interacting protein 1

Related Diseases

Diseases

Alias

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06019	HAUS7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HAUS7	MGD	MGI:1920988
Bos taurus	HAUS7	VGNC	VGNC:29762
Rattus norvegicus	HAUS7	RGD	RGD:1562991
Felis catus	HAUS7	VGNC	VGNC:62759
Canis familiaris	HAUS7	VGNC	VGNC:41607

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