2. Gene
  3. PRKACB - protein kinase cAMP-activated catalytic subunit beta Gene

PRKACB - protein kinase cAMP-activated catalytic subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAFD2; PKACB; PKA C-beta

Gene ID: 5567 | Gene type: protein coding

About PRKACB

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:84,078,079-84,238,498 (from NCBI)

This gene has 18 transcripts (splice variants), 302 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 61.5), colon (RPKM 21.8) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

PRKACB Products(30)

mRNA Protein Name
NM_001242857.3 NP_001229786.1 cAMP-dependent protein kinase catalytic subunit beta isoform 4
NM_001242858.3 NP_001229787.1 cAMP-dependent protein kinase catalytic subunit beta isoform 5
NM_001242859.3 NP_001229788.1 cAMP-dependent protein kinase catalytic subunit beta isoform 6
NM_001242860.3 NP_001229789.1 cAMP-dependent protein kinase catalytic subunit beta isoform 7
NM_001242861.3 NP_001229790.1 cAMP-dependent protein kinase catalytic subunit beta isoform 8
NM_001242862.3 NP_001229791.1 cAMP-dependent protein kinase catalytic subunit beta isoform 9
NM_001300915.2 NP_001287844.1 cAMP-dependent protein kinase catalytic subunit beta isoform 10
NM_001300916.2 NP_001287845.1 cAMP-dependent protein kinase catalytic subunit beta isoform 11
NM_001300917.2 NP_001287846.1 cAMP-dependent protein kinase catalytic subunit beta isoform 12
NM_001375560.1 NP_001362489.1 cAMP-dependent protein kinase catalytic subunit beta isoform 13
NM_001375561.1 NP_001362490.1 cAMP-dependent protein kinase catalytic subunit beta isoform 14
NM_001375562.1 NP_001362491.1 cAMP-dependent protein kinase catalytic subunit beta isoform 15
NM_001375563.1 NP_001362492.1 cAMP-dependent protein kinase catalytic subunit beta isoform 16
NM_001375564.1 NP_001362493.1 cAMP-dependent protein kinase catalytic subunit beta isoform 17
NM_001375565.1 NP_001362494.1 cAMP-dependent protein kinase catalytic subunit beta isoform 18
NM_001375569.1 NP_001362498.1 cAMP-dependent protein kinase catalytic subunit beta isoform 20
NM_001375571.1 NP_001362500.1 cAMP-dependent protein kinase catalytic subunit beta isoform 21
NM_001375572.1 NP_001362501.1 cAMP-dependent protein kinase catalytic subunit beta isoform 22
NM_001375573.1 NP_001362502.1 cAMP-dependent protein kinase catalytic subunit beta isoform 23
NM_001375574.1 NP_001362503.1 cAMP-dependent protein kinase catalytic subunit beta isoform 26
NM_001375575.1 NP_001362504.1 cAMP-dependent protein kinase catalytic subunit beta isoform 24
NM_001375576.1 NP_001362505.1 cAMP-dependent protein kinase catalytic subunit beta isoform 25
NM_001375577.1 NP_001362506.1 cAMP-dependent protein kinase catalytic subunit beta isoform 27
NM_001375578.1 NP_001362507.1 cAMP-dependent protein kinase catalytic subunit beta isoform 28
NM_001375579.1 NP_001362508.1 cAMP-dependent protein kinase catalytic subunit beta isforom 29
NM_001375580.1 NP_001362509.1 cAMP-dependent protein kinase catalytic subunit beta isoform 30
NM_001375581.1 NP_001362510.1 cAMP-dependent protein kinase catalytic subunit beta isoform 19
NM_002731.4 NP_002722.1 cAMP-dependent protein kinase catalytic subunit beta isoform 2
NM_182948.4 NP_891993.1 cAMP-dependent protein kinase catalytic subunit beta isoform 1
NM_207578.3 NP_997461.1 cAMP-dependent protein kinase catalytic subunit beta isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
12420224 GOA
enables cAMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
12420224 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12420224 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21880142 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
21423175 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
31112131 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12420224 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKACB Protein Structure

Pkinase

Pkinase: Protein kinase domain (45 - 298)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

cAMP-dependent protein kinase catalytic subunit beta

protein kinase A catalytic subunit beta

PRKACB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRKACB P22694 PKIA Homo sapiens P61925
Validated Y2H
32296183
Intra
PRKACB P22694 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
PRKACB P22694 HSP90AB1 Homo sapiens P08238
TAP
23455922
Intra
PRKACB P22694 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
PRKACB P22694 AVPI1 Homo sapiens Q5T686
Y2H Prey Pooling
32296183
Intra
PRKACB P22694 AVPI1 Homo sapiens Q5T686
Validated Y2H
32296183
Intra
PRKACB P22694 AVPI1 Homo sapiens Q5T686
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cardioacrofacial Dysplasia 2

CAFD2
Breast Ductal Adenoma
Breast Adenoma

Ademoma - Breast
Atrioventricular Septal Defect

AVSD

Atrioventricular Canal Defect

Avcd

Endocardial Cushion Defect

Ecd

Avc Defect

Atrioventricular Septal Defect, Susceptibility To, 1

Atrioventricular Septal Defect 1

Endocardial Cushion Defects

Septal Defect, Atrioventricular

Atrioventricular Defect With Atrial Shunting Only

Incomplete Atrioventricular Septal Defect With Isolated Atrial Component

Incomplete Atrioventricular Canal Defect With Isolated Atrial Component

Primum Atrial Septal Defect

Partial Atrioventricular Canal Defect With Isolated Atrial Component

Partial Atrioventricular Septal Defect, Ostium Primum Type

Ostium Primum Atrial Septal Defect

Partial Atrioventricular Canal Defect

Partial Atrioventricular Septal Defect

Atrial Septum Primum Defect

Atrioventricular Canal Defect With Isolated Ventricular Component

Atrioventricular Canal Defect With Isolated Ventricular Communication

Atrioventricular Septal Defect With Isolated Ventricular Component

Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting

Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve

Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves

Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect

Intermediate Atrioventricular Canal Defect

Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices

Intermediate Atrioventricular Septal Defect

Transitional Atrioventricular Canal Defect

Transitional Atrioventricular Septal Defect

Complete Atrioventricular Canal With Atrial And Ventricular Components

Complete Atrioventricular Canal Defect

Complete Atrioventricular Septal Defect
Melanotic Neurilemmoma

Melanotic Schwannoma

Pigmented Neurilemmoma

Pigmented Schwannoma
Cervical Non-Keratinizing Squamous Cell Carcinoma
Primary Pigmented Nodular Adrenocortical Disease

Ppnad

Primary Pigmented Nodular Adrenal Dysplasia

Pigmented Nodular Adrenocortical Disease, Primary, 2

Pigmented Nodular Adrenocortical Disease, Primary, 1
Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma

Fhcc

Fibrolamellar Hepatocarcinoma

Hepatocellular Carcinoma, Fibrolamellar

Oncocytic Hepatocellular Tumor

Eosinophilic Glassy Cell Hepatoma

Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis

Fl-Hcc

Fibrolamellar Oncocytic Hepatoma

Hepatocellular Carcinoma With Increased Stromal Fibrosis

Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Cervical Keratinizing Squamous Cell Carcinoma
Carney Complex Variant

Carney Complex

Carney Syndrome

Carney Complex, Type 1

Lamb Syndrome

Name Syndrome

Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome

Carney Complex - Trismus - Pseudocamptodactyly Syndrome

Carney Complex, Type 2

Car

Cnc1

Carney Myxoma-Endocrine Complex

Myxoma - Spotty Pigmentation - Endocrine Overactivity

Myxoma, Spotty Pigmentation, And Endocrine Overactivity

Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome

Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome

Carney Complex-Trismus-Pseudocamptodactyly Syndrome

CACOV
Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

Hereditary Thrombophilia Due To Congenital Hrg Deficiency

Thph11
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Mccune-Albright Syndrome

Mass Syndrome

Polyostotic Fibrous Dysplasia

MAS

Fibrous Dysplasia Of Bone

Albright Syndrome

Mass Phenotype

Overlap Connective Tissue Disease

Mccune Albright Syndrome

Osteitis Fibrosa Disseminata

OCTD

Albright'S Disease

Pfd

Pofd

Albright'S Syndrome

Mccune-Albright Syndrome, Somatic, Mosaic

Albright'S Disease Of Bone

Albright'S Syndrome With Precocious Puberty

Albright-Mccune-Sternberg Syndrome

Albright-Sternberg Syndrome

Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty

Gonadotropin-Independent Female-Limited Sexual Precocity

Fibrous Dysplasia Polyostotic

Fibrous Dysplasia, Polyostotic
Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4

Osteogenesis Imperfecta Type Iv

OI4

Oi, Type Iv

Osteogenesis Imperfecta With Normal Sclerae

Oi Type Iv

Oi Type 4

Osteogenesis Imperfecta With Normal Sclera

Common Variable Oi With Normal Sclerae

Osteogenesis Imperfecta 4

Oi-Iv
Brachydactyly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11107 PRKACB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRKACB VGNC VGNC:33321
Canis familiaris PRKACB VGNC VGNC:44971
Rattus norvegicus PRKACB RGD RGD:1310574
Mus musculus PRKACB MGD MGI:97594
Felis catus PRKACB VGNC VGNC:80322
Macaca mulatta PRKACB VGNC VGNC:97808
Others PRKACB NCBI