PKIA - cAMP-dependent protein kinase inhibitor alpha Gene

Homo sapiens

Also known as PRKACN1

Gene ID: 5569 | Gene type: protein coding

About PKIA

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:78,516,340-78,605,267 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues and 2 paralogues. Biased expression in heart (RPKM 28.1), brain (RPKM 26.1) and 11 other tissues.

Summary

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

PKIA Products(2)

mRNA	Protein	Name
NM_006823.4	NP_006814.1	cAMP-dependent protein kinase inhibitor alpha
NM_181839.3	NP_862822.1	cAMP-dependent protein kinase inhibitor alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	7905001	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20485264	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	21812984	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	7905001	GOA
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	21812984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKIA Protein Structure

PKI

0
76 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase inhibitor alpha

PKI-alpha

PKIA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PKIA	P61925	CRM1	Saccharomyces cerevisiae	P30822	Pull Down	20485264
Cross	PKIA	P61925	CRM1	Saccharomyces cerevisiae	P30822	FRET	20485264
Cross	PKIA	P61925	Xpo1	Mus musculus	Q6P5F9	GMS	20972448
Cross	PKIA	P61925	Xpo1	Mus musculus	Q6P5F9	FPS	20972448
Intra	PKIA	P61925	PRKACB	Homo sapiens	P22694	Y2H Array	32296183
Intra	PKIA	P61925	PRKACB	Homo sapiens	P22694	Y2H Prey Pooling	32296183
Intra	PKIA	P61925	MRNIP	Homo sapiens	Q6NTE8	Validated Y2H	32296183
Intra	PKIA	P61925	MRNIP	Homo sapiens	Q6NTE8	Y2H Prey Pooling	32296183
Intra	PKIA	P61925	MRNIP	Homo sapiens	Q6NTE8	Y2H Array	32296183
Intra	PKIA	P61925	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	PKIA	P61925	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	PKIA	P61925	DYNLL1	Homo sapiens	P63167	Validated Y2H	32296183
Intra	PKIA	P61925	XPO1	Homo sapiens	O14980	FRET	20485264
Intra	PKIA	P61925	CASP6	Homo sapiens	P55212	Y2H Array	32296183
Intra	PKIA	P61925	CASP6	Homo sapiens	P55212	Y2H Prey Pooling	32296183
Intra	PKIA	P61925	PRC1	Homo sapiens	O43663	Y2H Prey Pooling	32296183
Intra	PKIA	P61925	PRC1	Homo sapiens	O43663	Y2H Array	32296183
Intra	PKIA	P61925	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	32296183
Intra	PKIA	P61925	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	32296183
Intra	PKIA	P61925	DYNLL2	Homo sapiens	Q96FJ2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10598	PKIA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PKIA	RGD	RGD:621021
Bos taurus	PKIA	VGNC	VGNC:32940
Felis catus	PKIA	VGNC	VGNC:81705
Canis familiaris	PKIA	VGNC	VGNC:44607
Mus musculus	PKIA	MGD	MGI:104747

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