PRKAG1 - protein kinase AMP-activated non-catalytic subunit gamma 1 Gene

Homo sapiens

Also known as AMPKG

Gene ID: 5571 | Gene type: protein coding

About PRKAG1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,002,274-49,018,776 (from NCBI)

This gene has 20 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 18.1), adrenal (RPKM 16.8) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRKAG1 Products(3)

mRNA	Protein	Name
NM_001206709.2	NP_001193638.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 3
NM_001206710.2	NP_001193639.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 4
NM_002733.5	NP_002724.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	17028174	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	10698692	GOA
enables protein kinase regulator activity	IDA IDA: Inferred from direct assay	24563466	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17028174	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17028174	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	9693118	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9693118	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAG1 Protein Structure

CBS

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase subunit gamma-1

5'-AMP-activated protein kinase, gamma-1 subunit

Recombinant PRKAG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76141	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559)	≥95%
HY-P76142	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552)	≥95%
HY-P76143	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559)	≥95%
HY-P76144	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552)	≥95%

Related Diseases

Diseases

Alias

Malignant Essential Hypertension

Accelerated Essential Hypertension

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Dysferlinopathy

Dystrophinopathy

Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern	Wpw Syndrome
Anomalous Atrioventricular Excitation	Anomalous A-V Excitation
Ventricular Pre-Excitation With Arrhythmia	WPWS
Ventricular Familial Preexcitation Syndrome	Preexcitation Syndrome
Ventricular Preexcitation	Wpw - [Wolff-Parkinson- White] Syndrome
Pre-Excitation Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11109	PRKAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKAG1	MGD	MGI:108411
Macaca mulatta	PRKAG1	VGNC	VGNC:76405
Rattus norvegicus	PRKAG1	RGD	RGD:3388
Felis catus	PRKAG1	VGNC	VGNC:97568
Canis familiaris	PRKAG1	VGNC	VGNC:44972
Bos taurus	PRKAG1	VGNC	VGNC:33322
Others	PRKAG1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.