PRKAG1 - protein kinase AMP-activated non-catalytic subunit gamma 1 Gene

Homo sapiens

Also known as AMPKG

Gene ID: 5571 | Gene type: protein coding

About PRKAG1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,002,274-49,018,776 (from NCBI)

This gene has 20 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 18.1), adrenal (RPKM 16.8) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PRKAG1 Products(3)

mRNA	Protein	Name
NM_001206709.2	NP_001193638.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 3
NM_001206710.2	NP_001193639.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 4
NM_002733.5	NP_002724.1	5'-AMP-activated protein kinase subunit gamma-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	17028174	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	10698692	GOA
enables protein kinase regulator activity	IDA IDA: Inferred from direct assay	24563466	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17028174	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17028174	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	9693118	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9693118	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAG1 Protein Structure

CBS

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase subunit gamma-1

5'-AMP-activated protein kinase, gamma-1 subunit

PRKAG1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKAG1	P54619	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	32296183
Intra	PRKAG1	P54619	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	PRKAG1	P54619	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	PRKAG1	P54619	TEKT1	Homo sapiens	Q969V4	Validated Y2H	25416956
Intra	PRKAG1	P54619	TEKT1	Homo sapiens	Q969V4	Validated Y2H	32296183
Intra	PRKAG1	P54619	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	TEKT1	Homo sapiens	Q969V4	Y2H Array	32296183
Intra	PRKAG1	P54619	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	25416956
Intra	PRKAG1	P54619	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	32296183
Intra	PRKAG1	P54619	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	33961781
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	28514442
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Y2H Array	32296183
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	20562859
Intra	PRKAG1	P54619	PRKAB2	Homo sapiens	O43741	Y2H	21988832
Intra	PRKAG1	P54619	PRKAA1	Homo sapiens	Q13131	Anti Bait CoIP	22363791
Intra	PRKAG1	P54619	PRKAA1	Homo sapiens	Q13131	Anti Tag CoIP	33961781
Intra	PRKAG1	P54619	PRKAA1	Homo sapiens	Q13131	Y2H Prey Pooling	25416956
Intra	PRKAG1	P54619	PRKAA1	Homo sapiens	Q13131	Y2H Array	25416956
Intra	PRKAG1	P54619	PRKAA1	Homo sapiens	Q13131	Anti Tag CoIP	20562859
Intra	PRKAG1	P54619	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	PRKAG1	P54619	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	PRKAG1	P54619	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	33961781
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	28514442
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Validated Y2H	32296183
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Anti Tag CoIP	20562859
Intra	PRKAG1	P54619	PRKAA2	Homo sapiens	P54646	Y2H Array	32296183
Intra	PRKAG1	P54619	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	PRKAG1	P54619	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PRKAG1	P54619	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32296183
Intra	PRKAG1	P54619	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	TNFAIP1	Homo sapiens	Q13829	Validated Y2H	32296183
Intra	PRKAG1	P54619	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Anti Tag CoIP	18480843
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Anti Tag CoIP	28514442
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Anti Bait CoIP	22363791
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Validated Y2H	32296183
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Y2H Array	32296183
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Anti Tag CoIP	20562859
Intra	PRKAG1	P54619	PRKAB1	Homo sapiens	Q9Y478	Anti Tag CoIP	33961781
Intra	PRKAG1	P54619	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
Intra	PRKAG1	P54619	CBS	Homo sapiens	P35520	Y2H Prey Pooling	25416956
Intra	PRKAG1	P54619	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	PRKAG1	P54619	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	PRKAG1	P54619	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	PRKAG1	P54619	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	25416956
Intra	PRKAG1	P54619	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	PRKAG1	P54619	KEAP1	Homo sapiens	Q14145	Validated Y2H	32296183
Intra	PRKAG1	P54619	KEAP1	Homo sapiens	Q14145	Y2H Array	25416956
Intra	PRKAG1	P54619	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	PRKAG1	P54619	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	25416956
Intra	PRKAG1	P54619	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76141	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559)	≥95%
HY-P76142	AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552)	≥95%
HY-P76143	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559)	≥95%
HY-P76144	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552)	≥95%

PRKAG1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80543	AMPK gamma 1 Antibody	WB, ICC/IF, IP	Human

Related Diseases

Diseases

Alias

Malignant Essential Hypertension

Accelerated Essential Hypertension

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Dysferlinopathy

Dystrophinopathy

Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern	Wpw Syndrome
Anomalous Atrioventricular Excitation	Anomalous A-V Excitation
Ventricular Pre-Excitation With Arrhythmia	WPWS
Ventricular Familial Preexcitation Syndrome	Preexcitation Syndrome
Ventricular Preexcitation	Wpw - [Wolff-Parkinson- White] Syndrome
Pre-Excitation Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11109	PRKAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKAG1	MGD	MGI:108411
Macaca mulatta	PRKAG1	VGNC	VGNC:76405
Rattus norvegicus	PRKAG1	RGD	RGD:3388
Felis catus	PRKAG1	VGNC	VGNC:97568
Canis familiaris	PRKAG1	VGNC	VGNC:44972
Bos taurus	PRKAG1	VGNC	VGNC:33322
Others	PRKAG1	NCBI

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