PCID2 - PCI domain containing 2 Gene

Homo sapiens

Also known as F10

Gene ID: 55795 | Gene type: protein coding

About PCID2

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,165,002-113,208,669 (from NCBI)

This gene has 16 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 6.6), ovary (RPKM 4.5) and 25 other tissues.

Summary

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast Cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PCID2 Products(14)

mRNA	Protein	Name
NM_001127202.4	NP_001120674.1	PCI domain-containing protein 2 isoform 1
NM_001127203.4	NP_001120675.1	PCI domain-containing protein 2 isoform 1
NM_001258213.3	NP_001245142.1	PCI domain-containing protein 2 isoform 3
NM_001320655.2	NP_001307584.1	PCI domain-containing protein 2 isoform 3
NM_001320656.2	NP_001307585.1	PCI domain-containing protein 2 isoform 2
NM_001320657.2	NP_001307586.1	PCI domain-containing protein 2 isoform 4
NM_001320659.2	NP_001307588.1	PCI domain-containing protein 2 isoform 5
NM_001320660.2	NP_001307589.1	PCI domain-containing protein 2 isoform 6
NM_001353091.2	NP_001340020.1	PCI domain-containing protein 2 isoform 7
NM_001353092.2	NP_001340021.1	PCI domain-containing protein 2 isoform 3
NM_001353093.2	NP_001340022.1	PCI domain-containing protein 2 isoform 7
NM_001353094.2	NP_001340023.1	PCI domain-containing protein 2 isoform 7
NM_001353095.2	NP_001340024.1	PCI domain-containing protein 2 isoform 8
NM_018386.5	NP_060856.2	PCI domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22343721	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20870947	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	20870947	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20870947	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	20870947	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	20870947	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23591820	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	23591820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23591820	GOA
part of transcription export complex 2	IDA IDA: Inferred from direct assay	23591820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCID2 Protein Structure

PCI

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

PCI domain-containing protein 2

CSN12-like protein

PCID2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCID2	Q5JVF3	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	PCID2	Q5JVF3	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	PCID2	Q5JVF3	SEM1	Homo sapiens	P60896	Y2H Prey Pooling	32296183
Intra	PCID2	Q5JVF3	SEM1	Homo sapiens	P60896	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10150	PCID2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PCID2	VGNC	VGNC:44305
Mus musculus	PCID2	MGD	MGI:2443003
Felis catus	PCID2	VGNC	VGNC:64069
Macaca mulatta	PCID2	VGNC	VGNC:75680
Rattus norvegicus	PCID2	RGD	RGD:1307041
Bos taurus	PCID2	VGNC	VGNC:32629

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