KDM3A - lysine demethylase 3A Gene

Homo sapiens

Also known as TSGA; JMJD1; JHDM2A; JHMD2A; JMJD1A

Gene ID: 55818 | Gene type: protein coding

About KDM3A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,437,044-86,492,716 (from NCBI)

This gene has 15 transcripts (splice variants), 128 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 32.2), bone marrow (RPKM 27.1) and 25 other tissues.

Summary

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

KDM3A Products(2)

mRNA	Protein	Name
NM_001146688.2	NP_001140160.1	lysine-specific demethylase 3A
NM_018433.6	NP_060903.2	lysine-specific demethylase 3A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K9 demethylase activity	IMP IMP: Inferred from mutant phenotype	28262558	GOA
enables histone H3K9me/H3K9me2 demethylase activity	IDA IDA: Inferred from direct assay	16603237	GOA
enables iron ion binding	IMP IMP: Inferred from mutant phenotype	16603237	GOA
enables nuclear androgen receptor binding	IDA IDA: Inferred from direct assay	16603237	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25535969	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	16603237	GOA
involved in formaldehyde biosynthetic process	IDA IDA: Inferred from direct assay	16603237	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	16603237	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16603237	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16603237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM3A Protein Structure

JmjC

0
300
600
900
1200
1321 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 3A

[histone H3]-dimethyl-L-lysine(9) demethylase 3A

KDM3A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KDM3A	Q9Y4C1	STAT1	Homo sapiens	P42224-1	Anti Tag CoIP	25535969
Intra	KDM3A	Q9Y4C1	STAT1	Homo sapiens	P42224-1	Anti Bait CoIP	25535969
Intra	KDM3A	Q9Y4C1	RPS6KA5	Homo sapiens	O75582-1	Anti Tag CoIP	25535969
Intra	KDM3A	Q9Y4C1	RPS6KA5	Homo sapiens	O75582	Anti Bait CoIP	25535969
Intra	KDM3A	Q9Y4C1	RPS6KA5	Homo sapiens	O75582	Anti Tag CoIP	25535969

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12304	IOX1	Inhibitor	99.72%	Unkown
HY-168593	Wnt/β-catenin-IN-5		/	Unkown
HY-RS07211	KDM3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KDM3A	VGNC	VGNC:42322
Bos taurus	KDM3A	VGNC	VGNC:30525
Rattus norvegicus	KDM3A	RGD	RGD:708351
Mus musculus	KDM3A	MGD	MGI:98847
Felis catus	KDM3A	VGNC	VGNC:63070
Macaca mulatta	KDM3A	VGNC	VGNC:73871

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