PBK - PDZ binding kinase Gene

Homo sapiens

Also known as SPK; CT84; TOPK; HEL164; Nori-3

Gene ID: 55872 | Gene type: protein coding

About PBK

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,809,624-27,837,817 (from NCBI)

This gene has 4 transcripts (splice variants) and 208 orthologues. Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues.

Summary

This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PBK Products(3)

mRNA	Protein	Name
NM_001278945.2	NP_001265874.1	lymphokine-activated killer T-cell-originated protein kinase isoform 2
NM_018492.4	NP_060962.2	lymphokine-activated killer T-cell-originated protein kinase isoform 1
NM_001363040.2	NP_001349969.1	lymphokine-activated killer T-cell-originated protein kinase isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10779557	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25575812	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PBK Protein Structure

Pkinase

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

lymphokine-activated killer T-cell-originated protein kinase

MAPKK-like protein kinase	T-LAK cell-originated protein kinase
cancer/testis antigen 84	epididymis luminal protein 164
serine/threonine protein kinase	spermatogenesis-related protein kinase

Recombinant PBK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77122	PBK/TOPK Protein, Human (sf9, His)	Q96KB5-1 (M1-V322)	≥95%

Related Diseases

Diseases

Alias

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Perforated Corneal Ulcer

Hematologic Cancer

Hematologic Neoplasm	Hematologic Malignancies
Hematologic Neoplasms	Blood Cancer
Hematologic Malignancy	Hematological Tumors
Hematopoietic And Lymphoid System Tumor	Hematopoietic Cancer
Hematopoietic Neoplasm	Hematopoietic Tumors
Malignant Hematopoietic Neoplasm	Liquid Tumor
Hematopoietic Neoplasms

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Corneal Edema

Corneal Oedema

Infiltrate Of Cornea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120346	PBK-IN-9	Inhibitor	/	Unkown
HY-RS10101	PBK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10102	Pbk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10103	Pbk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PBK	VGNC	VGNC:75643
Mus musculus	PBK	MGD	MGI:1289156
Bos taurus	PBK	VGNC	VGNC:59199
Felis catus	PBK	VGNC	VGNC:64054
Rattus norvegicus	PBK	RGD	RGD:1309565
Others	PBK	NCBI

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