2. Gene
  3. LANCL2 - LanC like glutathione S-transferase 2 Gene

LANCL2 - LanC like glutathione S-transferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TASP; GPR69B

Gene ID: 55915 | Gene type: protein coding

About LANCL2

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:55,365,337-55,433,737 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 16.9), testis (RPKM 9.1) and 24 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LANCL2 Products(1)

mRNA Protein Name
NM_018697.4 NP_061167.1 lanC-like protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
16979580 GOA
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
16979580 GOA
enables phosphatidylinositol-5-phosphate binding IDA
IDA: Inferred from direct assay
16979580 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12566319 GOA
involved in positive regulation of abscisic acid-activated signaling pathway IDA
IDA: Inferred from direct assay
19667068 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
16979580 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12566319 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12566319 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12566319 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LANCL2 Protein Structure

LANC_like

LANC_like: Lanthionine synthetase C-like protein (97 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

lanC-like protein 2

G protein-coupled receptor 69B

LANCL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LANCL2 Q9NS86 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Prey Pooling
32296183
Intra
LANCL2 Q9NS86 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32296183
Intra
LANCL2 Q9NS86 TDRKH Homo sapiens Q9Y2W6
Y2H Prey Pooling
32296183
Intra
LANCL2 Q9NS86 TDRKH Homo sapiens Q9Y2W6
Validated Y2H
32296183
Intra
LANCL2 Q9NS86 TDRKH Homo sapiens Q9Y2W6
Y2H Array
32296183
Intra
LANCL2 Q9NS86 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
LANCL2 Q9NS86 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
LANCL2 Q9NS86 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
LANCL2 Q9NS86 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
LANCL2 Q9NS86 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-100560 Abscisic acid Inhibitor 99.72% Phase 4
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102013 Omilancor 98.44% Unkown
HY-RS07519 LANCL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LANCL2 VGNC VGNC:49916
Felis catus LANCL2 VGNC VGNC:68017
Mus musculus LANCL2 MGD MGI:1919085
Rattus norvegicus LANCL2 RGD RGD:1310809
Bos taurus LANCL2 VGNC VGNC:30784
Macaca mulatta LANCL2 VGNC VGNC:81630