2. Gene
  3. KLHL9 - kelch like family member 9 Gene

KLHL9 - kelch like family member 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 55958 | Gene type: protein coding

About KLHL9

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,329,665-21,335,404 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues, 54 paralogues and is associated with 1 phenotype.

Summary

This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 Ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein Aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]

KLHL9 Products(1)

mRNA Protein Name
NM_018847.4 NP_061335.1 kelch-like protein 9
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cullin family protein binding IPI
IPI: Inferred from physical interaction
14528312 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17543862 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17543862 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
17543862 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
17543862 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17543862 GOA
located in midbody IDA
IDA: Inferred from direct assay
19995937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL9 Protein Structure

BTB

BTB: BTB/POZ domain (40 - 146)

BACK

BACK: BTB And C-terminal Kelch (154 - 255)

Kelch_1

Kelch_1: Kelch motif (336 - 386)

Kelch_1

Kelch_1: Kelch motif (394 - 433)

Kelch_1

Kelch_1: Kelch motif (437 - 479)

Kelch_1

Kelch_1: Kelch motif (485 - 531)

Kelch_1

Kelch_1: Kelch motif (536 - 577)

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  • 617 a.a.
Protein Preferred Names Protein Names

kelch-like protein 9

KLHL9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KLHL9 Q9P2J3 CUL3 Homo sapiens Q13618
Anti Tag CoIP
30190310
Intra KLHL9 Q9P2J3 CUL3 Homo sapiens Q13618
Anti Tag CoIP
20554658
Intra KLHL9 Q9P2J3 CUL3 Homo sapiens Q13618
Anti Bait CoIP
17543862
Intra KLHL9 Q9P2J3 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
17543862
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Klhl9-Related Early-Onset Distal Myopathy
Nemaline Myopathy 9

NEM9

Myopathy, Nemaline, Type 9
Fatal Infantile Hypertonic Myofibrillar Myopathy
Myopathy, Distal, 4

Distal Myopathy With Posterior Leg And Anterior Hand Involvement

MPD4

Williams Distal Myopathy

Distal Muscular Dystrophy 4

Distal Abd-Filaminopathy

Distal Myopathy 4

Myopathy, Distal, Type 4
Tibial Muscular Dystrophy

Tmd

Udd Myopathy

Distal Titinopathy

Finnish Tibial Muscular Dystrophy

Tardive Tibial Muscular Dystrophy

Udd Type Distal Myopathy

Udd Distal Myopathy

Udd-Markesbery Muscular Dystrophy

Distal Myopathy, Udd Type

Distal Myopathies

Tibial Muscular Dystrophy, Tardive
Myopathy, Myofibrillar, 9, With Early Respiratory Failure

Hereditary Myopathy With Early Respiratory Failure

Hmerf

Myopathy, Proximal, With Early Respiratory Muscle Involvement

Edstrom Myopathy

Mfm-Titinopathy

MFM9

Mprm

Hereditary Inclusion Body Myopathy With Early Respiratory Failure

Hibm-Erf

Myofibrillar Myopathy-Titinopathy

Myofibrillar Myopathy With Early Respiratory Failure

Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant

Myofibrillar Myopathy 9

Myofibrillar Myopathy 9 With Early Respiratory Failure

Autosomal Dominant Distal Myopathy With Early Respiratory Failure

Proximal Myopathy With Early Respiratory Muscle Involvement

Hereditary Proximal Myopathy With Early Respiratory Failure

Admerf

Edström Myopathy

Hmerf-Erf
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07372 KLHL9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KLHL9 VGNC VGNC:30671
Felis catus KLHL9 VGNC VGNC:82345
Mus musculus KLHL9 MGD MGI:2180122
Macaca mulatta KLHL9 VGNC VGNC:74080
Rattus norvegicus KLHL9 RGD RGD:1304814