2. Gene
  3. MAPK4 - mitogen-activated protein kinase 4 Gene

MAPK4 - mitogen-activated protein kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK

Gene ID: 5596 | Gene type: protein coding

About MAPK4

Cytogenetic location: 18q21.1-q21.2 Genomic coordinates (GRCh38): 18:50,559,612-50,731,826 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 207 orthologues and 19 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues.

Summary

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MAPK4 Products(3)

mRNA Protein Name
NM_001292039.2 NP_001278968.1 mitogen-activated protein kinase 4 isoform 2
NM_001292040.2 NP_001278969.1 mitogen-activated protein kinase 4 isoform 3
NM_002747.4 NP_002738.2 mitogen-activated protein kinase 4 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 312)

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  • 587 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 4

Erk3-related

MAPK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
MAPK4 P31152 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-154987 MARK4 inhibitor 3 98.23% Unkown
HY-RS08116 MAPK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAPK4 RGD RGD:3047
Canis familiaris MAPK4 VGNC VGNC:42998
Mus musculus MAPK4 MGD MGI:2444559
Bos taurus MAPK4 VGNC VGNC:31220
Macaca mulatta MAPK4 VGNC VGNC:74647
Felis catus MAPK4 VGNC VGNC:68169
Others MAPK4 NCBI