NSFL1C - NSFL1 cofactor Gene

Homo sapiens

Also known as P47; UBX1; UBXD10; UBXN2C; dJ776F14.1

Gene ID: 55968 | Gene type: protein coding

About NSFL1C

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,442,166-1,466,849 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 11.4), brain (RPKM 10.1) and 25 other tissues.

Summary

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

NSFL1C Products(3)

mRNA	Protein	Name
NM_001206736.2	NP_001193665.1	NSFL1 cofactor p47 isoform d
NM_016143.5	NP_057227.2	NSFL1 cofactor p47 isoform a
NM_018839.5	NP_061327.2	NSFL1 cofactor p47 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of mitotic spindle orientation	IGI IGI: Inferred from genetic interaction	23649807	GOA
involved in negative regulation of protein localization to centrosome	IGI IGI: Inferred from genetic interaction	23649807	GOA
involved in positive regulation of mitotic centrosome separation	IGI IGI: Inferred from genetic interaction	23649807	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of VCP-NSFL1C complex	IPI IPI: Inferred from physical interaction	21645854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSFL1C Protein Structure

UBA_4

SEP

UBX

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

NSFL1 cofactor p47

NSFL1 (p97) cofactor (p47)

NSFL1C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Anti Tag CoIP	22466964
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	BRET	29997244
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Y2H Array	25416956
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Y2H	21900206
Intra	NSFL1C	Q9UNZ2	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
Intra	NSFL1C	Q9UNZ2	TARDBP	Homo sapiens	Q13148	Y2H Pooling	16169070

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09592	NSFL1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NSFL1C	MGD	MGI:3042273
Canis familiaris	NSFL1C	VGNC	VGNC:43984
Bos taurus	NSFL1C	VGNC	VGNC:32275
Rattus norvegicus	NSFL1C	RGD	RGD:619952
Macaca mulatta	NSFL1C	VGNC	VGNC:75407
Felis catus	NSFL1C	VGNC	VGNC:63887

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