PROS1 - protein S Gene

Homo sapiens

Also known as PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6

Gene ID: 5627 | Gene type: protein coding

About PROS1

Cytogenetic location: 3q11.1 Genomic coordinates (GRCh38): 3:93,873,051-93,973,896 (from NCBI)

This gene has 12 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 4 phenotypes. Broad expression in liver (RPKM 79.4), heart (RPKM 44.6) and 21 other tissues.

Summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant Protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

PROS1 Products(2)

mRNA	Protein	Name
NM_000313.4	NP_000304.2	vitamin K-dependent protein S isoform 2 preproprotein
NM_001314077.2	NP_001301006.1	vitamin K-dependent protein S isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	14607961	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROS1 Protein Structure

Gla

EGF

FXa_inhibition

EGF_CA

Laminin_G_1

Laminin_G_2

0
200
400
600
676 a.a.

Protein Preferred Names

Protein Names

vitamin K-dependent protein S

protein S (alpha)

PROS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PROS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74614	Protein S/PROS1 Protein, Human (HEK293, His)	P07225 (N25-S676)	≥95%

Related Diseases

Diseases

Alias

Thrombophilia Due To Protein S Deficiency, Autosomal Recessive

THPH6	Autosomal Recessive Thrombophilia Due To Congenital Protein S Deficiency
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency	Thrombophilia 5 Due To Protein S Deficiency, Autosomal Recessive
Autosomal Recessive Thrombophilia Due To Protein S Deficiency

Thrombophilia Due To Protein S Deficiency, Autosomal Dominant

THPH5	Thrombophilia 5 Due To Protein S Deficiency, Autosomal Dominant
Autosomal Dominant Thrombophilia Due To Protein S Deficiency	Thrombophilia Autosomal Dominant Due To Protein S Deficiency
Thrombophilia Autosomal Recessive Due To Protein S Deficiency

Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency

Thrombophilia

Hypercoagulability State

Prostatitis

Thrombosis

Thrombosis Of Blood Vessel

Purpura Fulminans

Purpura Gangrenosa

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities	Superficial Thrombophlebitis Of Leg
Thrombophlebitis Of A Superficial Leg Vein	Thrombophlebitis Of Superficial Veins Of Lower Extremity

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Coumarin Resistance

Warfarin Resistance	Warfarin Sensitivity
Coumadin Sensitivity	Warfarin Response
Poor Metabolism Of Coumarin	Coumarin, Poor Metabolism Of
CMRES

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1

VKCFD1	Combined Deficiency Of Vitamin K-Dependent Clotting Factors 1
Vitamin K-Dependent Coagulation Defect	Multiple Coagulation Factor Deficiency Iii
Mcfd3	Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 1
Vkcfd	Familial Multiple Coagulation Factor Deficiency Iii
Fmfd Iii	Factors Ii, Vii, Ix, And X, Combined Deficiency Of
Glutamic Acid, Deficient Gamma-Carboxylation Of

Vitamin K Deficiency Bleeding

Vitamin K Deficiency	Deficiency Of Vitamin K
Vitamin K	Vitamin K Deficiency Hemorrhagic Disease

Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors

Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X

Vkcfd

Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2

VKCFD2	Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2

Bile Duct Adenoma

Cholangioadenoma	Adenoma Bile Duct
Adenoma, Bile Duct

Nail Disorder, Nonsyndromic Congenital, 1

Nonsyndromic Congenital Nail Disorder 1	Twenty-Nail Dystrophy
Claw-Shaped Nails	Nail Disorder, Nonsyndromic Congenital, 10
Onycholysis	NDNC1
Onychauxis, Hyponychia, And Onycholysis	Nonsyndromic Congenital Nail Disorder 10
Idiopathic Trachyonychia	Twenty Nail Dystrophy
Ndnc10	Onychodystrophy Totalis, Isolated
Nail Disorder, Nonsyndromic Congenital, 10, Formerly	Ndnc10, Formerly
Autosomal Dominant Nail Dysplasia	Nail Disorder, Nonsyndromic Congenital 1
Onychodystrophy Totalis	Sandpaper Nails
Trachyonychia	Nail Disorder, Non-Syndromic Congenital, 1
Nail Disorder, Non-Syndromic Congenital, 10	Onychauxis Hyponychia And Onycholysis
Nail Disorder, Nonsyndromic Congenital, Type 10	Detachment Of Nail
Separation Of Nail Plate

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Meckel Syndrome, Type 7

Meckel Syndrome 7	Nphp3-Related Meckel-Like Syndrome
MKS7	Goldston Syndrome
Meckel Syndrome Type 7	Meckel-Like Syndrome Type 1
Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome	Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst
Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst	Meckel-Gruber Syndrome, Type 7
Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0917	TO-PRO 1		≥96.0%	Unkown
HY-136298A	X77	Inhibitor	99.95%	Unkown
HY-110084	BTZO-1		99.69%	Unkown
HY-136298	(Rac)-X77	Inhibitor	99.65%	Unkown
HY-P4388A	Z-Arg-Leu-Arg-Gly-Gly-AMC acetate		98.85%	Unkown
HY-149655	D1N8	Inhibitor	/	Unkown
HY-154976	SARS-CoV-2-IN-50	Inhibitor	/	Unkown
HY-D0918	YO-PRO-1		98.20%	Unkown
HY-P4388	Z-Arg-Leu-Arg-Gly-Gly-AMC		/	Unkown
HY-RS11202	PROS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157145	SARS-CoV-2-IN-69	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PROS1	VGNC	VGNC:102809
Rattus norvegicus	PROS1	RGD	RGD:620971
Canis familiaris	PROS1	VGNC	VGNC:53085
Mus musculus	PROS1	MGD	MGI:1095733
Bos taurus	PROS1	VGNC	VGNC:49565
Macaca mulatta	PROS1	VGNC	VGNC:76426
Others	PROS1	NCBI

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