GKN1 - gastrokine 1 Gene

Homo sapiens

Also known as FOV; CA11; AMP18; BRICD1; foveolin

Gene ID: 56287 | Gene type: protein coding

About GKN1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,974,636-68,980,976 (from NCBI)

This gene has 3 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 11425.3).

Summary

The protein encoded by this gene is found to be down-regulated in human gastric Cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GKN1 Products(1)

mRNA	Protein	Name
NM_019617.4	NP_062563.4	gastrokine-1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15221938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GKN1 Protein Structure

BRICHOS

0
100
199 a.a.

Protein Preferred Names

Protein Names

gastrokine-1

18 kDa antrum mucosa protein

GKN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GKN1	Q9NS71	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	GKN1	Q9NS71	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GKN1	Q9NS71	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GKN1	Q9NS71	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GKN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76356	Gastrokine 1 Protein, Human (sf9, His)	Q9NS71 (N35-N199)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05461	GKN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GKN1	VGNC	VGNC:41246
Mus musculus	GKN1	MGD	MGI:1913533
Bos taurus	GKN1	VGNC	VGNC:29388
Felis catus	GKN1	VGNC	VGNC:62570
Rattus norvegicus	GKN1	RGD	RGD:735014
Others	GKN1	NCBI

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