2. Gene
  3. VAPA - VAMP associated protein A Gene

VAPA - VAMP associated protein A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VAP-A; VAP33; VAMP-A; VAP-33; hVAP-33

Gene ID: 9218 | Gene type: protein coding

About VAPA

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,914,016-9,960,021 (from NCBI)

This gene has 9 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 26.8), brain (RPKM 22.1) and 25 other tissues.

Summary

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the Cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

VAPA Products(2)

mRNA Protein Name
NM_003574.6 NP_003565.4 vesicle-associated membrane protein-associated protein A isoform 1
NM_194434.3 NP_919415.2 vesicle-associated membrane protein-associated protein A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FFAT motif binding IDA
IDA: Inferred from direct assay
33124732 GOA
enables FFAT motif binding IMP
IMP: Inferred from mutant phenotype
18713837 GOA
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
18713837 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10544080 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
20178991 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
9920726 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
33124732 GOA
Biological Process GO Annotation Evidence Reference Source
involved in COPII-coated vesicle budding IMP
IMP: Inferred from mutant phenotype
18713837 GOA
involved in ceramide transport IMP
IMP: Inferred from mutant phenotype
12023275 GOA
involved in cholesterol transport IDA
IDA: Inferred from direct assay
33124732 GOA
NOT involved in endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
18713837 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
18713837 GOA
involved in endoplasmic reticulum-plasma membrane tethering IDA
IDA: Inferred from direct assay
33124732 GOA
involved in negative regulation by host of viral genome replication IDA
IDA: Inferred from direct assay
19515777 GOA
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
19289470 GOA
involved in phospholipid transport IDA
IDA: Inferred from direct assay
24209621 GOA
involved in positive regulation by host of viral genome replication IDA
IDA: Inferred from direct assay
19515777 GOA
NOT involved in protein folding in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
18713837 GOA
involved in protein localization to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
19289470 GOA
involved in sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
12023275 GOA
involved in sterol transport IDA
IDA: Inferred from direct assay
24209621 GOA
involved in viral release from host cell IDA
IDA: Inferred from direct assay
19515777 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
24209621 GOA
colocalizes with bicellular tight junction IDA
IDA: Inferred from direct assay
10523508 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18713837 GOA
NOT located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
18713837 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12023275 GOA
colocalizes with perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16895911 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10523508 GOA
located in vesicle IDA
IDA: Inferred from direct assay
10523508 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAPA Protein Structure

Motile_Sperm

Motile_Sperm: MSP (Major sperm protein) domain (15 - 117)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

vesicle-associated membrane protein-associated protein A

33 kDa VAMP-associated protein

VAPA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra VAPA Q9P0L0 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra VAPA Q9P0L0 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra VAPA Q9P0L0 PGRMC2 Homo sapiens O15173
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra VAPA Q9P0L0 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra VAPA Q9P0L0 RMDN3 Homo sapiens Q96TC7
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 RMDN3 Homo sapiens Q96TC7
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 RMDN3 Homo sapiens Q96TC7
Anti Tag CoIP
26496610
Intra VAPA Q9P0L0 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra VAPA Q9P0L0 VAPB Homo sapiens O95292
Anti Tag CoIP
26496610
Intra VAPA Q9P0L0 VAPB Homo sapiens O95292
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 VAPB Homo sapiens O95292
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 VAPB Homo sapiens O95292
Anti Tag CoIP
16227268
Intra VAPA Q9P0L0 SLC35B1 Homo sapiens P78383
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 SLC35B1 Homo sapiens P78383
Y2H Array
32296183
Intra VAPA Q9P0L0 TMEM229B Homo sapiens Q8NBD8
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 TMEM229B Homo sapiens Q8NBD8
Y2H Array
32296183
Intra VAPA Q9P0L0 RSAD2 Homo sapiens Q8WXG1
Anti Tag CoIP
21957124
Intra VAPA Q9P0L0 RSAD2 Homo sapiens Q8WXG1
Confocal
21957124
Intra VAPA Q9P0L0 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra VAPA Q9P0L0 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra VAPA Q9P0L0 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra VAPA Q9P0L0 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 USP20 Homo sapiens Q9Y2K6
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 USP20 Homo sapiens Q9Y2K6
Y2H Array
32296183
Intra VAPA Q9P0L0 USP20 Homo sapiens Q9Y2K6
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra VAPA Q9P0L0 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 OPRM1 Homo sapiens P35372
Ub Reconstruction
23840749
Intra VAPA Q9P0L0 OPRM1 Homo sapiens P35372
Anti Tag CoIP
23840749
Intra VAPA Q9P0L0 OPRM1 Homo sapiens P35372
Ub Reconstruction
28298427
Intra VAPA Q9P0L0 OSBP Homo sapiens P22059
Anti Tag CoIP
26496610
Intra VAPA Q9P0L0 OSBP Homo sapiens P22059
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 OSBP Homo sapiens P22059
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 YIF1A Homo sapiens O95070
Anti Tag CoIP
26496610
Intra VAPA Q9P0L0 YIF1A Homo sapiens O95070
IF
23736259
Intra VAPA Q9P0L0 YIF1A Homo sapiens O95070
Pull Down
23736259
Intra VAPA Q9P0L0 RMDN2 Homo sapiens Q96LZ7
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 RMDN2 Homo sapiens Q96LZ7
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 OSBPL2 Homo sapiens Q9H1P3
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra VAPA Q9P0L0 EGFR Homo sapiens P00533
Ub Reconstruction
20029029
Intra VAPA Q9P0L0 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra VAPA Q9P0L0 HACD3 Homo sapiens Q9P035
Anti Tag CoIP
18160438
Intra VAPA Q9P0L0 HACD3 Homo sapiens Q9P035
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 ZFYVE27 Homo sapiens Q5T4F4
Anti Tag CoIP
19289470
Intra VAPA Q9P0L0 ZFYVE27 Homo sapiens Q5T4F4
Anti Tag CoIP
35271311
Intra VAPA Q9P0L0 ZFYVE27 Homo sapiens Q5T4F4
Confocal
19289470
Intra VAPA Q9P0L0 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra VAPA Q9P0L0 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra VAPA Q9P0L0 GKN1 Homo sapiens Q9NS71
Y2H Array
32296183
Intra VAPA Q9P0L0 GKN1 Homo sapiens Q9NS71
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra VAPA Q9P0L0 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra VAPA Q9P0L0 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 ZBTB22 Homo sapiens O15209
Y2H Array
32296183
Intra VAPA Q9P0L0 ZBTB22 Homo sapiens O15209
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra VAPA Q9P0L0 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 OSBPL1A Homo sapiens Q9BXW6
Anti Tag CoIP
33961781
Intra VAPA Q9P0L0 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra VAPA Q9P0L0 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra VAPA Q9P0L0 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra VAPA Q9P0L0 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra VAPA Q9P0L0 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra VAPA Q9P0L0 VAPB Homo sapiens O95292-1
Anti Tag CoIP
19515777
Intra VAPA Q9P0L0 STARD3 Homo sapiens Q14849-1
FRET
24105263
Cross VAPA Q9P0L0 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Anti Tag CoIP
21957124
Cross VAPA Q9P0L0 P27958-PRO_0000037577 Hepatitis C virus P27958-PRO_0000037577
Anti Tag CoIP
16227268
Cross VAPA Q9P0L0 P27958-PRO_0000037577 Hepatitis C virus P27958-PRO_0000037577
Anti Tag CoIP
10544080
Cross VAPA Q9P0L0 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Y2H
10544080
Cross VAPA Q9P0L0 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Anti Tag CoIP
16227268
Cross VAPA Q9P0L0 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Pull Down
10544080
Cross VAPA Q9P0L0 P27958-PRO_0000037576 Hepatitis C virus P27958-PRO_0000037576
Anti Tag CoIP
10544080
Cross VAPA Q9P0L0 Q03463-PRO_0000278740 Hepatitis C virus Q03463-PRO_0000278740
Confocal
16227268
Cross VAPA Q9P0L0 Q03463-PRO_0000278740 Hepatitis C virus Q03463-PRO_0000278740
Y2H
16227268
Cross VAPA Q9P0L0 Q03463-PRO_0000278740 Hepatitis C virus Q03463-PRO_0000278740
Anti Tag CoIP
19515777
Cross VAPA Q9P0L0 Q03463-PRO_0000278741 Hepatitis C virus Q03463-PRO_0000278741
Anti Tag CoIP
16227268
Cross VAPA Q9P0L0 Q9WMX2-PRO_0000037552 Hepatitis C virus Q9WMX2-PRO_0000037552
Anti Tag CoIP
21957124
Cross VAPA Q9P0L0 Q99IB8-PRO_0000045600 Hepatitis C virus Q99IB8-PRO_0000045600
Anti Bait CoIP
25616068
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Wound Botulism

Cutaneous Infectious Botulism

Cutaneous Toxin-Mediated Botulism

Inoculation Botulism

Skin Infectious Botulism

Skin Toxin-Mediated Botulism
Infant Botulism

Infant Intestinal Botulism

Infant Intestinal Toxemia Botulism

Infant Intestinal Toxin-Mediated Botulism

Infantile Botulism

Botulism, Infantile
Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8

ALS8

Sclerosis, Lateral, Amyotrophic, Type Type 8
Retinal Dystrophy With Leukodystrophy

RDLKD

Acbd5 Deficiency

Dystrophy, Retinal, With Leukodystrophy
Anismus
Mesenteric Lymphadenitis

Mesenteric Adenitis
Intestinal Botulism

Intestinal Colonization Botulism

Intestinal Toxemia Botulism

Intestinal Toxin-Mediated Botulism
Hyperhidrosis, Gustatory

Frey Syndrome

Gustatory Sweating

Auriculotemporal Nerve Syndrome

Gustatory Hyperhidrosis

Frey'S Syndrome

Sweating, Gustatory

HYPRG

Baillarger Syndrome

Hyperhidrosis Gustatory

Auriculotemporal Syndrome
Bronchopneumonia

Lobular Pneumonia

Bronchial Pneumonia

Chest Infection - Bronchopneumonia
Cervical Dystonia

Spasmodic Torticollis
Subacute Leukemia
Choreoacanthocytosis

Chorea-Acanthocytosis

CHAC

Acanthocytosis With Neurologic Disorder

Levine-Critchley Syndrome

Choreaacanthocytosis

Chorea Acanthocytosis

Neuroacanthocytosis

Levine-Critchley Syndrome, Formerly

Neuroacanthocytosis, Formerly

Choreo-Acanthocytosis

Acanthocytosis Chorea

Chorea Acanthocytosis Syndrome
Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

Als6

Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

Autosomal Recessive Amyotrophic Lateral Sclerosis 6

Sclerosis, Lateral, Amyotrophic, Type Type 6

Amyotrophic Lateral Sclerosis 6
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15602 VAPA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VAPA VGNC VGNC:36763
Canis familiaris VAPA VGNC VGNC:48229
Mus musculus VAPA MGD MGI:1353561
Rattus norvegicus VAPA RGD RGD:61803
Felis catus VAPA VGNC VGNC:66917