UBE2J1 - ubiquitin conjugating enzyme E2 J1 Gene

Homo sapiens

Also known as UBC6; UBC6E; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243

Gene ID: 51465 | Gene type: protein coding

About UBE2J1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,326,625-89,352,722 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 49.6), bone marrow (RPKM 46.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

UBE2J1 Products(1)

mRNA	Protein	Name
NM_016021.3	NP_057105.2	ubiquitin-conjugating enzyme E2 J1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IDA IDA: Inferred from direct assay	33472082	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19690564	GOA
enables ubiquitin conjugating enzyme activity	IMP IMP: Inferred from mutant phenotype	21245296	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11439185	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERAD pathway	IMP IMP: Inferred from mutant phenotype	21245296	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	22607976	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	33472082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2J1 Protein Structure

UQ_con

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 J1

E2 ubiquitin-conjugating enzyme J1

UBE2J1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2J1	Q9Y385	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	UBE2J1	Q9Y385	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	PROKR2	Homo sapiens	Q8NFJ6	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	PROKR2	Homo sapiens	Q8NFJ6	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	PLPPR2	Homo sapiens	Q96GM1	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	PLPPR2	Homo sapiens	Q96GM1	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	CDS1	Homo sapiens	Q92903	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	CDS1	Homo sapiens	Q92903	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	MS4A6E	Homo sapiens	Q96DS6	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	MS4A6E	Homo sapiens	Q96DS6	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	SLC26A5	Homo sapiens	P58743-6	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	SLC26A5	Homo sapiens	P58743-6	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	33961781
Intra	UBE2J1	Q9Y385	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	28514442
Intra	UBE2J1	Q9Y385	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	LAPTM5	Homo sapiens	Q13571	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	LAPTM5	Homo sapiens	Q13571	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	CLTRN	Homo sapiens	Q9HBJ8	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	GKN1	Homo sapiens	Q9NS71	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	GKN1	Homo sapiens	Q9NS71	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	DERL1	Homo sapiens	Q9BUN8	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	DERL1	Homo sapiens	Q9BUN8	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	LY6G6C	Homo sapiens	O95867	Y2H Prey Pooling	32296183
Intra	UBE2J1	Q9Y385	LY6G6C	Homo sapiens	O95867	Y2H Array	32296183
Intra	UBE2J1	Q9Y385	SYVN1	Homo sapiens	Q86TM6	Y2H Array	19690564

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15350	UBE2J1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2J1	MGD	MGI:1926245
Canis familiaris	UBE2J1	VGNC	VGNC:48055
Rattus norvegicus	UBE2J1	RGD	RGD:1305067
Felis catus	UBE2J1	VGNC	VGNC:66760
Macaca mulatta	UBE2J1	VGNC	VGNC:83963
Bos taurus	UBE2J1	VGNC	VGNC:36585
Others	UBE2J1	NCBI

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