UBE2J1 - ubiquitin conjugating enzyme E2 J1 Gene

Homo sapiens

Also known as UBC6; UBC6E; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243

Gene ID: 51465 | Gene type: protein coding

About UBE2J1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,326,625-89,352,722 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 49.6), bone marrow (RPKM 46.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

UBE2J1 Products(1)

mRNA	Protein	Name
NM_016021.3	NP_057105.2	ubiquitin-conjugating enzyme E2 J1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IDA IDA: Inferred from direct assay	33472082	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19690564	GOA
enables ubiquitin conjugating enzyme activity	IMP IMP: Inferred from mutant phenotype	21245296	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11439185	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ERAD pathway	IMP IMP: Inferred from mutant phenotype	21245296	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	22607976	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	33472082	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2J1 Protein Structure

UQ_con

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 J1

E2 ubiquitin-conjugating enzyme J1

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15350	UBE2J1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2J1	MGD	MGI:1926245
Canis familiaris	UBE2J1	VGNC	VGNC:48055
Rattus norvegicus	UBE2J1	RGD	RGD:1305067
Felis catus	UBE2J1	VGNC	VGNC:66760
Macaca mulatta	UBE2J1	VGNC	VGNC:83963
Bos taurus	UBE2J1	VGNC	VGNC:36585
Others	UBE2J1	NCBI

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