2. Gene
  3. PRPSAP1 - phosphoribosyl pyrophosphate synthetase associated protein 1 Gene

PRPSAP1 - phosphoribosyl pyrophosphate synthetase associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAP39

Gene ID: 5635 | Gene type: protein coding

About PRPSAP1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,309,478-76,354,198 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 21.2), testis (RPKM 17.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PRPSAP1 Products(3)

mRNA Protein Name
NM_001330503.2 NP_001317432.1 phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 2
NM_001366236.2 NP_001353165.1 phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 2
NM_002766.3 NP_002757.2 phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPSAP1 Protein Structure

Pribosyltran_N

Pribosyltran_N: N-terminal domain of ribose phosphate pyrophosphokinase (44 - 155)

Pribosyl_synth

Pribosyl_synth: Phosphoribosyl synthetase-associated domain (196 - 379)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

phosphoribosyl pyrophosphate synthase-associated protein 1

39 kDa phosphoribosypyrophosphate synthase-associated protein

PRPSAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRPSAP1 Q14558 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
PRPSAP1 Q14558 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
PRPSAP1 Q14558 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
PRPSAP1 Q14558 CAPN7 Homo sapiens Q9Y6W3
Validated Y2H
32296183
Intra
PRPSAP1 Q14558 PRPS2 Homo sapiens P11908
Anti Tag CoIP
33961781
Intra
PRPSAP1 Q14558 PRPSAP1 Homo sapiens Q14558
Y2H Pooling
16189514
Intra
PRPSAP1 Q14558 PRPSAP1 Homo sapiens Q14558
Y2H Pooling
19447967
Intra
PRPSAP1 Q14558 PRPS1 Homo sapiens P60891
Y2H Array
31515488
Intra
PRPSAP1 Q14558 PRPSAP1 Homo sapiens Q14558
Y2H Prey Pooling
32296183
Intra
PRPSAP1 Q14558 PRPSAP1 Homo sapiens Q14558
Validated Y2H
32296183
Intra
PRPSAP1 Q14558 PRPSAP1 Homo sapiens Q14558
Y2H Array
32296183
Intra
PRPSAP1 Q14558 PRPSAP2 Homo sapiens O60256
Y2H Prey Pooling
32296183
Intra
PRPSAP1 Q14558 PRPSAP2 Homo sapiens O60256
Y2H Array
32296183
Intra
PRPSAP1 Q14558 PRPSAP2 Homo sapiens O60256
Anti Tag CoIP
33961781
Intra
PRPSAP1 Q14558 MAGOHB Homo sapiens Q96A72
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Bardet-Biedl Syndrome 7

BBS7

Bardet-Biedl Syndrome, Type 7
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5

CMTX5

Rosenberg-Chutorian Syndrome

Charcot-Marie-Tooth Disease X-Linked Recessive 5

Optic Atrophy, Polyneuropathy, And Deafness

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5

Cmt5x

X-Linked Charcot-Marie-Tooth Disease Type 5

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5

Optic Atrophy Polyneuropathy Deafness

Optic Atrophy With Polyneuropathy And Deafness

Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5
Arts Syndrome

ARTS

Mrxsarts

Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision

Mrxs18

Lethal Ataxia With Deafness And Optic Atrophy

Fatal X-Linked Ataxia With Deafness And Loss Of Vision

Mental Retardation, X-Linked, Syndromic, Arts Type

Mental Retardation, X-Linked, Syndromic 18

Syndromic X-Linked Mental Retardation 18

Syndromic X-Linked Mental Retardation Arts Type

Lethal Ataxia-Deafness-Optic Atrophy

X-Linked Fatal Ataxia With Deafness And Loss Of Vision

Ataxia-Deafness-Optic Atrophy, Lethal

Lethal Ataxia With Hearing Loss And Optic Atrophy

Art
Deafness, X-Linked 1

DFNX1

Dfn2

Deafness, X-Linked 2, Sensorineural Congenital

X-Linked Deafness 1

X-Linked Sensorineural Congenital Deafness 2

Deafness, X-Linked, 1

Congenital Sensorineural Deafness X-Linked 2

Deafness, X-Linked, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11221 PRPSAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRPSAP1 VGNC VGNC:45034
Bos taurus PRPSAP1 VGNC VGNC:33386
Macaca mulatta PRPSAP1 VGNC VGNC:76429
Rattus norvegicus PRPSAP1 RGD RGD:620206
Mus musculus PRPSAP1 MGD MGI:1915013
Felis catus PRPSAP1 VGNC VGNC:97569