2. Gene
  3. Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rip3; 2610528K09Rik

Gene ID: 56532 | Gene type: protein coding

About Ripk3

Chromosome 14: 56,022,452-56,026,322 reverse strand.GRCm39:CM001007.3

This gene has 9 transcripts (splice variants), 245 orthologues, 23 paralogues and is associated with 11 phenotypes. Broad expression in large intestine adult (RPKM 17.7), thymus adult (RPKM 1.3) and 18 other tissues.

Summary

Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ripk3 Products(3)

mRNA Protein Name
NM_001164108.1 NP_001157580.1 receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_001164107.1 NP_001157579.1 receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_019955.2 NP_064339.2 receptor-interacting serine/threonine-protein kinase 3 isoform 1

Ripk3 Protein Structure

PKc_like

PKc_like: cl21453 (27 - 283)

RHIM

RHIM: pfam12721 (412 - 456)

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  • 486 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 3

RIP-3

RIP-like protein kinase 3

mRIP3

receptor interacting protein 3

Recombinant Ripk3 Proteins

Cat. No. Product Name Accession Purity
HY-P71853 RIPK3 Protein, Mouse (P.pastoris, His) Q9QZL0 (M1-K486) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101872 GSK-872 Inhibitor 99.91% Unkown
HY-101872A GSK-872 hydrochloride Inhibitor 99.21% Unkown
HY-125402 GSK-843 Inhibitor 99.18% Unkown
HY-131064 RIPK3-IN-1 Inhibitor 99.19% Unkown
HY-158312 UH15-38 Inhibitor 99.80% Unkown
HY-148365 NecroIr1 Activator 98.02% Unkown
HY-148366 NecroIr2 Activator 98.99% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-149052 SZM-1209 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk3 NCBI NCBI:11035