Ripk3 - receptor-interacting serine-threonine kinase 3 Gene

Mus musculus

Also known as Rip3; 2610528K09Rik

Gene ID: 56532 | Gene type: protein coding

About Ripk3

Chromosome 14: 56,022,452-56,026,322 reverse strand.GRCm39:CM001007.3

This gene has 9 transcripts (splice variants), 245 orthologues, 23 paralogues and is associated with 11 phenotypes. Broad expression in large intestine adult (RPKM 17.7), thymus adult (RPKM 1.3) and 18 other tissues.

Summary

Enables NF-kappaB-inducing kinase activity and protein serine/threonine kinase activity. Involved in several processes, including execution phase of necroptosis; hematopoietic or lymphoid organ development; and regulation of programmed cell death. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of protein deacetylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; male reproductive gland or organ; primitive streak; and turbinate bone primordium. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ripk3 Products(3)

mRNA	Protein	Name
NM_001164108.1	NP_001157580.1	receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_001164107.1	NP_001157579.1	receptor-interacting serine/threonine-protein kinase 3 isoform 2
NM_019955.2	NP_064339.2	receptor-interacting serine/threonine-protein kinase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19498109	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10490590	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	24012422	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation in thymus	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in T cell homeostasis	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	27258785	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	22423968	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27321907	MGI
involved in execution phase of necroptosis	IMP IMP: Inferred from mutant phenotype	27746097	MGI
involved in lymph node development	IGI IGI: Inferred from genetic interaction	21876153	MGI
acts upstream of or within necroptotic process	IGI IGI: Inferred from genetic interaction	19498109	MGI
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	24012422	MGI
acts upstream of or within positive effect non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25367573	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10490590	MGI
acts upstream of or within positive regulation of ligase activity	IDA IDA: Inferred from direct assay	19498109	MGI
involved in positive regulation of necroptotic process	IDA IDA: Inferred from direct assay	22423968	MGI
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within positive regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	19498109	MGI
acts upstream of or within positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19498109	MGI
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within positive regulation of transferase activity	IGI IGI: Inferred from genetic interaction	19498109	MGI
involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	27258785	MGI
acts upstream of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19498109	MGI
involved in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in regulation of T cell mediated cytotoxicity	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in regulation of activated T cell proliferation	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in regulation of activation-induced cell death of T cells	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in regulation of adaptive immune response	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	32200799	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	27321907	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
involved in regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in spleen development	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in thymus development	IGI IGI: Inferred from genetic interaction	21876153	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28607035	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10490590	MGI
located in nucleus	IDA IDA: Inferred from direct assay	28607035	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ripk3 Protein Structure

PKc_like

RHIM

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

receptor-interacting serine/threonine-protein kinase 3

RIP-3	RIP-like protein kinase 3
mRIP3	receptor interacting protein 3

Recombinant Ripk3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71853	RIPK3 Protein, Mouse (P.pastoris, His)	Q9QZL0 (M1-K486)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101872	GSK-872	Inhibitor	99.91%	Unkown
HY-101872A	GSK-872 hydrochloride	Inhibitor	99.21%	Unkown
HY-125402	GSK-843	Inhibitor	99.18%	Unkown
HY-131064	RIPK3-IN-1	Inhibitor	99.19%	Unkown
HY-158312	UH15-38	Inhibitor	99.80%	Unkown
HY-148365	NecroIr1	Activator	98.02%	Unkown
HY-148366	NecroIr2	Activator	98.99%	Unkown
HY-151873	SZM679	Inhibitor	99.59%	Unkown
HY-149052	SZM-1209	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ripk3	NCBI	NCBI:11035

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