2. Gene
  3. Mlkl - mixed lineage kinase domain-like Gene

Mlkl - mixed lineage kinase domain-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 9130019I15Rik

Gene ID: 74568 | Gene type: protein coding

About Mlkl

Summary

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced Necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in Necroptosis pathway. Knockout of this gene in mice showed that it is essential for Necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Mlkl Products(2)

mRNA Protein Name
NM_001310613.1 NP_001297542.1 mixed lineage kinase domain-like protein isoform 1
NM_029005.3 NP_083281.1 mixed lineage kinase domain-like protein isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
24012422 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22265413 MGI
NOT enables protein kinase activity IDA
IDA: Inferred from direct assay
24012422 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
24012422 MGI
Biological Process GO Annotation Evidence Reference Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
32200799 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27321907 MGI
involved in execution phase of necroptosis IDA
IDA: Inferred from direct assay
32200799 MGI
involved in execution phase of necroptosis IMP
IMP: Inferred from mutant phenotype
27321907 MGI
involved in necroptotic process IMP
IMP: Inferred from mutant phenotype
23835476 MGI
involved in necroptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
22265413 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
32200799 MGI
located in nucleus IDA
IDA: Inferred from direct assay
32200799 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
32200799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mixed lineage kinase domain-like protein

Mlkl Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Mlkl Q9D2Y4 Ripk3 Mus musculus Q9QZL0
Anti Tag CoIP
26559832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100573 Necrosulfonamide Inhibitor 99.47% Unkown
HY-10587 BIX-01294 98.44% Unkown
HY-112292 GW806742X Inhibitor 99.91% Unkown
HY-144828 RIP1/RIP3/MLKL activator 1 ≥97.0% Unkown
HY-101524 TC13172 Inhibitor 99.04% Unkown
HY-112292A GW806742X hydrochloride Inhibitor 98.77% Unkown
HY-148365 NecroIr1 98.02% Unkown
HY-156591 PROTAC MLKL Degrader-1 Degrader 99.76% Unkown
HY-156119 MLKL-IN-6 Inhibitor 98.57% Unkown
HY-157039 RIPK1-IN-17 Inhibitor 98.38% Unkown
HY-141889 MLKL-IN-2 Inhibitor 99.83% Unkown
HY-148366 NecroIr2 98.99% Unkown
HY-100573A (E/Z)-Necrosulfonamide Inhibitor 98.84% Unkown
HY-100573S Necrosulfonamide-d4 Inhibitor 99.26% Unkown
HY-162424 ZBP1/RIP3/MLKL activator 1 Activator / Unkown
HY-108239 BIX-01294 trihydrochloride / Unkown
HY-139878 MLKL-IN-1 Inhibitor / Unkown
HY-148767 MLKL-IN-5 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-149393 RIPK3-IN-3 Inhibitor / Unkown
HY-151541 MLKL-IN-3 Inhibitor / Unkown
HY-161361 MLKL-IN-7 Inhibitor / Unkown
HY-168640 RIP3 activator 1 / Unkown
HY-169072 PROTAC MLKL Degrader-2 / Unkown
HY-169073 TC13172-NH-COOH / Unkown
HY-169074 Thalidomide-N-methylpiperazine / Unkown
HY-169509 Topoisomerase I/II inhibitor 8 / Unkown
HY-RS08492 MLKL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-151542 MLKL-IN-4 Inhibitor / Unkown
HY-N8380 (-)-Latifolin / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlkl NCBI NCBI:197259