2. Gene
  3. Ripk1 - receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene

Ripk1 - receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as RIP; Rinp; Rip1; RIP-1; D330015H01Rik

Gene ID: 19766 | Gene type: protein coding

About Ripk1

Chromosome 13: 34,186,346-34,221,130 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 198 orthologues, 23 paralogues and is associated with 21 phenotypes. Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ripk1 Products(2)

mRNA Protein Name
NM_001359997.1 NP_001346926.1 receptor-interacting serine/threonine-protein kinase 1
NM_009068.3 NP_033094.3 receptor-interacting serine/threonine-protein kinase 1

Ripk1 Protein Structure

PKc_like

PKc_like: cl21453 (22 - 290)

Death_RIP1

Death_RIP1: cd08777 (567 - 652)

  • 0
  • 200
  • 400
  • 600
  • 656 a.a.
Protein Preferred Names Protein Names

receptor-interacting serine/threonine-protein kinase 1

cell death protein RIP

receptor-interacting protein 1

serine/threonine-protein kinase RIP

Related Agents

Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14622A Necrostatin 2 racemate Inhibitor 99.65% Unkown
HY-134050 Apostatin-1 Inhibitor 99.24% Unkown
HY-138779 ICCB-19 hydrochloride Inhibitor 99.24% Unkown
HY-128348 PK68 Inhibitor 99.92% Unkown
HY-124546 Necrostatin-5 Inhibitor 98.43% Unkown
HY-132203 Necrostatin-34 Inhibitor 98.90% Unkown
HY-148365 NecroIr1 Activator 98.02% Unkown
HY-18901 RIPK1-IN-4 Inhibitor 98.89% Unkown
HY-149258 KWCN-41 Inhibitor 99.83% Unkown
HY-148366 NecroIr2 Activator 98.99% Unkown
HY-151873 SZM679 Inhibitor 99.59% Unkown
HY-153437 RIP1 kinase inhibitor 7 Inhibitor / Unkown
HY-18899 Nec-3a Inhibitor / Unkown
HY-169107 RIPK1-IN-25 Inhibitor / Unkown
HY-149052 SZM-1209 Inhibitor / Unkown
HY-146758 RIPK1-IN-14 Inhibitor / Unkown
HY-153434 RIP1 kinase inhibitor 4 Inhibitor / Unkown
HY-160216 RIPK1-IN-18 Inhibitor / Unkown
HY-157963 RIPK1-IN-23 Inhibitor / Unkown
HY-157456 RIPK1-IN-19 Inhibitor ≥98.0% Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-162237 RIPK1-IN-22 Inhibitor / Unkown
HY-161911 Necroptosis-IN-5 Inhibitor / Unkown
HY-148297 Ocadusertib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ripk1 NCBI NCBI:8737
Canis familiaris Ripk1 NCBI NCBI:102152063
Macaca fascicularis Ripk1 NCBI NCBI:101926590
Canis lupus familiaris Ripk1 NCBI
Rattus norvegicus Ripk1 NCBI NCBI:306886