Ripk1 - receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene

Mus musculus

Also known as RIP; Rinp; Rip1; RIP-1; D330015H01Rik

Gene ID: 19766 | Gene type: protein coding

About Ripk1

Chromosome 13: 34,186,346-34,221,130 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 198 orthologues, 23 paralogues and is associated with 21 phenotypes. Ubiquitous expression in ovary adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ripk1 Products(2)

mRNA	Protein	Name
NM_001359997.1	NP_001346926.1	receptor-interacting serine/threonine-protein kinase 1
NM_009068.3	NP_033094.3	receptor-interacting serine/threonine-protein kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16680093	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29440439	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	25015821	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	28701375	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27819682	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	18641653	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	28842570	MGI
involved in cellular response to growth factor stimulus	IMP IMP: Inferred from mutant phenotype	20125124	MGI
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	27258785	MGI
involved in necroptotic process	IDA IDA: Inferred from direct assay	28701375	MGI
acts upstream of or within necroptotic process	IGI IGI: Inferred from genetic interaction	19498109	MGI
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	28842570	MGI
involved in necroptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24813849	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	22089168	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	20125124	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	24813849	MGI
involved in peptidyl-serine autophosphorylation	IMP IMP: Inferred from mutant phenotype	31827281	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	20125124	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	20125124	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20125124	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22089168	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	9529147	MGI
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	26555174	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	19498109	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	31827281	MGI
involved in positive regulation of interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	31827281	MGI
involved in positive regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within positive regulation of transferase activity	IGI IGI: Inferred from genetic interaction	19498109	MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	30439713	MGI
involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	27258785	MGI
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	29440439	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21052097	MGI
acts upstream of or within ripoptosome assembly involved in necroptotic process	IGI IGI: Inferred from genetic interaction	21052097	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ripk1 Protein Structure

PKc_like

Death_RIP1

0
200
400
600
656 a.a.

Protein Preferred Names

Protein Names

receptor-interacting serine/threonine-protein kinase 1

cell death protein RIP	receptor-interacting protein 1
serine/threonine-protein kinase RIP

Ripk1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ripk1	Q60855	Tradd	Mus musculus	Q3U0V2	Anti Tag CoIP	18719121
Intra	Ripk1	Q60855	Ripk3	Mus musculus	Q9QZL0	Anti Bait CoIP	19524513
Intra	Ripk1	Q60855	Rps27a	Mus musculus	P62991	Comigration in SDS	18719121
Intra	Ripk1	Q60855	Tnfrsf1a	Mus musculus	P25118	Anti Bait CoIP	16680093
Intra	Ripk1	Q60855	Fadd	Mus musculus	Q61160	Anti Bait CoIP	26555174

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14622A	Necrostatin 2 racemate	Inhibitor	99.65%	Unkown
HY-134050	Apostatin-1	Inhibitor	99.84%	Unkown
HY-14622	Necrostatin 2	Inhibitor	99.92%	Unkown
HY-138779	ICCB-19 hydrochloride	Inhibitor	99.24%	Unkown
HY-128348	PK68	Inhibitor	99.92%	Unkown
HY-124546	Necrostatin-5	Inhibitor	98.43%	Unkown
HY-132203	Necrostatin-34	Inhibitor	98.90%	Unkown
HY-18901	RIPK1-IN-4	Inhibitor	98.89%	Unkown
HY-148365	NecroIr1	Activator	98.02%	Unkown
HY-149258	KWCN-41	Inhibitor	99.83%	Unkown
HY-148366	NecroIr2	Activator	98.99%	Unkown
HY-151873	SZM679	Inhibitor	99.59%	Unkown
HY-153437	RIP1 kinase inhibitor 7	Inhibitor	/	Unkown
HY-157963	RIPK1-IN-23	Inhibitor	/	Unkown
HY-169107	RIPK1-IN-25	Inhibitor	/	Unkown
HY-149052	SZM-1209	Inhibitor	/	Unkown
HY-161911	Necroptosis-IN-5	Inhibitor	/	Unkown
HY-146758	RIPK1-IN-14	Inhibitor	/	Unkown
HY-148297	Ocadusertib	Inhibitor	/	Unkown
HY-18899	Nec-3a	Inhibitor	/	Unkown
HY-160216	RIPK1-IN-18	Inhibitor	/	Unkown
HY-157456	RIPK1-IN-19	Inhibitor	≥98.0%	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-162237	RIPK1-IN-22	Inhibitor	/	Unkown
HY-153434	RIP1 kinase inhibitor 4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ripk1	NCBI	NCBI:8737
Canis familiaris	Ripk1	NCBI	NCBI:102152063
Macaca fascicularis	Ripk1	NCBI	NCBI:101926590
Canis lupus familiaris	Ripk1	NCBI
Rattus norvegicus	Ripk1	NCBI	NCBI:306886

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