Sphk2 - sphingosine kinase 2 Gene

Mus musculus

Also known as Sk2; Spk2

Gene ID: 56632 | Gene type: protein coding

About Sphk2

Chromosome 7: 45,358,891-45,367,426 reverse strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 209 orthologues, 4 paralogues and is associated with 5 phenotypes. Ubiquitous expression in duodenum adult (RPKM 72.1), adrenal adult (RPKM 42.9) and 28 other tissues.

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances Apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Sphk2 Products(3)

mRNA	Protein	Name
NM_203280.3	NP_975009.1	sphingosine kinase 2
NM_020011.5	NP_064395.2	sphingosine kinase 2
NM_001172561.1	NP_001166032.1	sphingosine kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-erythro-sphingosine kinase activity	IDA IDA: Inferred from direct assay	10751414	MGI
enables D-erythro-sphingosine kinase activity	IMP IMP: Inferred from mutant phenotype	16093248	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16316995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blood vessel development	IGI IGI: Inferred from genetic interaction	16314531	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	16314531	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16314531	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	16118219	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16118219	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16314531	MGI
involved in positive regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16118219	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in positive regulation of mast cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	25637806	MGI
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17346996	MGI
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	20959514	MGI
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	25637806	MGI
involved in sphinganine-1-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	10751414	MGI
acts upstream of or within sphingosine metabolic process	IMP IMP: Inferred from mutant phenotype	16093248	MGI
involved in sphingosine metabolic process	IMP IMP: Inferred from mutant phenotype	17346996	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16118219	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10751414	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16118219	MGI
located in membrane	IDA IDA: Inferred from direct assay	10751414	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	20959514	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	25637806	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20959514	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk2 Protein Structure

PLN02958

0
100
200
300
400
500
617 a.a.

Protein Preferred Names

Protein Names

sphingosine kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15779A	K145 hydrochloride	Inhibitor	99.88%	Unkown
HY-12892	SKI-178	Inhibitor	98.91%	Unkown
HY-147282	Amgen-23	Inhibitor	99.00%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-151350	SphK2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sphk2	NCBI	NCBI:56848

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