SPHK2 - sphingosine kinase 2 Gene

Homo sapiens

Also known as SK 2; SK-2; SPK 2; SPK-2

Gene ID: 56848 | Gene type: protein coding

About SPHK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,619,506-48,630,405 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.4), duodenum (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and Apoptosis, and also plays a role in several types of Cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast Cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

SPHK2 Products(13)

mRNA	Protein	Name
XM_017027008.2	XP_016882497.1	sphingosine kinase 2 isoform X1
XM_011527134.2	XP_011525436.1	sphingosine kinase 2 isoform X3
XM_047439106.1	XP_047295062.1	sphingosine kinase 2 isoform X3
XM_011527133.2	XP_011525435.1	sphingosine kinase 2 isoform X2
NM_020126.5	NP_064511.2	sphingosine kinase 2 isoform a
NM_001204159.3	NP_001191088.1	sphingosine kinase 2 isoform a
NM_001204160.3	NP_001191089.1	sphingosine kinase 2 isoform c
NM_001204158.3	NP_001191087.1	sphingosine kinase 2 isoform b
XM_006723292.2	XP_006723355.1	sphingosine kinase 2 isoform X3
XM_047439107.1	XP_047295063.1	sphingosine kinase 2 isoform X4
NM_001243876.2	NP_001230805.1	sphingosine kinase 2 isoform d
XM_047439108.1	XP_047295064.1	sphingosine kinase 2 isoform X4
XM_017027010.3	XP_016882499.1	sphingosine kinase 2 isoform X4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-erythro-sphingosine kinase activity	IDA IDA: Inferred from direct assay	10751414	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19729656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11777919	GOA
enables sphingosine kinase activity	IDA IDA: Inferred from direct assay	19729656	GOA
enables sphingosine-1-phosphate receptor activity	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	17635916	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16118219	GOA
involved in positive regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16118219	GOA
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	20959514	GOA
involved in sphinganine-1-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	10751414	GOA
involved in sphingosine biosynthetic process	IGI IGI: Inferred from genetic interaction	23106337	GOA
involved in sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19729656	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16103110	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10751414	GOA
located in membrane	IDA IDA: Inferred from direct assay	10751414	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	19729656	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16103110	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPHK2 Protein Structure

DAGK_cat

0
200
400
600
654 a.a.

Protein Preferred Names

Protein Names

sphingosine kinase 2

SPHK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ureteral Obstruction

Brachydactyly, Type E1

Brachydactyly Type E1	Brachydactyly Type E
BDE1	Brachydactyly, Type E
Bde	Type E Brachydactyly
Brachydactyly E1	Brachydactyly Syndrome Type E

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15779A	K145 hydrochloride	Inhibitor	99.88%	Unkown
HY-12892	SKI-178	Inhibitor	98.91%	Unkown
HY-147282	Amgen-23	Inhibitor	99.00%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-151350	SphK2-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPHK2	VGNC	VGNC:35211
Rattus norvegicus	SPHK2	RGD	RGD:1307757
Macaca mulatta	SPHK2	VGNC	VGNC:77960
Mus musculus	SPHK2	MGD	MGI:1861380
Canis familiaris	SPHK2	VGNC	VGNC:46737
Others	SPHK2	NCBI

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