ZC3HAV1 - zinc finger CCCH-type containing, antiviral 1 Gene

Homo sapiens

Also known as ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2

Gene ID: 56829 | Gene type: protein coding

About ZC3HAV1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:139,043,515-139,109,720 (from NCBI)

This gene has 5 transcripts (splice variants), 124 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues.

Summary

This gene encodes a CCCH-type zinc finger protein. This Antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]

ZC3HAV1 Products(3)

mRNA	Protein	Name
NM_001363491.2	NP_001350420.1	zinc finger CCCH-type antiviral protein 1 isoform 3
NM_020119.4	NP_064504.2	zinc finger CCCH-type antiviral protein 1 isoform 1
NM_024625.4	NP_078901.3	zinc finger CCCH-type antiviral protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables NAD+ binding	IMP IMP: Inferred from mutant phenotype	25635049	GOA
NOT enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	25635049	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21102435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	21102435	GOA
involved in positive regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	21102435	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21102435	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	21102435	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	21102435	GOA
involved in positive regulation of mRNA catabolic process	IDA IDA: Inferred from direct assay	21876179	GOA
NOT involved in protein poly-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	25635049	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	21876179	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21102435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3HAV1 Protein Structure

PARP

0
200
400
600
800
902 a.a.

Protein Preferred Names

Protein Names

zinc finger CCCH-type antiviral protein 1

ADP-ribosyltransferase diphtheria toxin-like 13

ZC3HAV1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZC3HAV1	Q7Z2W4	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	ZC3HAV1	Q7Z2W4	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	ZC3HAV1	Q7Z2W4	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ZC3HAV1	Q7Z2W4	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ZC3HAV1	Q7Z2W4	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15997	ZC3HAV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZC3HAV1	VGNC	VGNC:48563
Mus musculus	ZC3HAV1	MGD	MGI:1926031
Bos taurus	ZC3HAV1	VGNC	VGNC:37111
Macaca mulatta	ZC3HAV1	VGNC	VGNC:79408
Felis catus	ZC3HAV1	VGNC	VGNC:67191
Rattus norvegicus	ZC3HAV1	RGD	RGD:628694

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