PSMA5 - proteasome 20S subunit alpha 5 Gene

Homo sapiens

Also known as PSC5; ZETA

Gene ID: 5686 | Gene type: protein coding

About PSMA5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,399,042-109,426,448 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 14.6), appendix (RPKM 13.2) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PSMA5 Products(4)

mRNA	Protein	Name
NM_001199772.2	NP_001186701.1	proteasome subunit alpha type-5 isoform 2
NM_001199773.2	NP_001186702.1	proteasome subunit alpha type-5 isoform 2
NM_001199774.2	NP_001186703.1	proteasome subunit alpha type-5 isoform 2
NM_002790.4	NP_002781.2	proteasome subunit alpha type-5 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15225636	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome core complex, alpha-subunit complex	IDA IDA: Inferred from direct assay	30133132	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMA5 Protein Structure

Proteasome_A_N

Proteasome

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

proteasome subunit alpha type-5

epididymis tissue sperm binding protein Li 11n

PSMA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMA5	P28066	PSMA4	Homo sapiens	P25789	Pull Down	15225636
Intra	PSMA5	P28066	PSMA4	Homo sapiens	P25789	Anti Tag CoIP	33961781
Intra	PSMA5	P28066	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	33961781
Intra	PSMA5	P28066	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor	Nonanaplastic Renal Wilm'S Tumour
Nonanaplastic Renal Wilms Tumor	Renal Wilms' Tumour

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11295	PSMA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMA5	RGD	RGD:61848
Mus musculus	PSMA5	MGD	MGI:1347009
Canis familiaris	PSMA5	VGNC	VGNC:54060
Macaca mulatta	PSMA5	VGNC	VGNC:76440
Felis catus	PSMA5	VGNC	VGNC:80331
Bos taurus	PSMA5	VGNC	VGNC:33440

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