1. Gene
  2. PSMA4 - proteasome 20S subunit alpha 4 Gene

PSMA4 - proteasome 20S subunit alpha 4 Gene

Homo sapiens

Also known as HC9; PSC9; HsT17706

Gene ID: 5685 | Gene type: protein coding

About PSMA4

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,540,405-78,552,417 (from NCBI)

This gene has 21 transcripts (splice variants), 245 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 63.8), lymph node (RPKM 63.8) and 25 other tissues.

Summary

This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave Peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]

PSMA4 Products(6)

mRNA Protein Name
NM_001102667.2 NP_001096137.1 proteasome subunit alpha type-4 isoform 1
NM_001102668.3 NP_001096138.1 proteasome subunit alpha type-4 isoform 2
NM_001330673.2 NP_001317602.1 proteasome subunit alpha type-4 isoform 3
NM_001330675.2 NP_001317604.1 proteasome subunit alpha type-4 isoform 4
NM_001330676.2 NP_001317605.1 proteasome subunit alpha type-4 isoform 1
NM_002789.6 NP_002780.1 proteasome subunit alpha type-4 isoform 1

PSMA4 Protein Structure

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (5 - 27)

Proteasome

Proteasome: Proteasome subunit (30 - 215)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

proteasome subunit alpha type-4

macropain subunit C9

PSMA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PSMA4 P25789 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra PSMA4 P25789 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra PSMA4 P25789 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra PSMA4 P25789 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra PSMA4 P25789 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra PSMA4 P25789 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra PSMA4 P25789 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra PSMA4 P25789 TRIM38 Homo sapiens O00635
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 PSMA3 Homo sapiens P25788
Y2H
14733938
Intra PSMA4 P25789 PSMA3 Homo sapiens P25788
Pull Down
15225636
Intra PSMA4 P25789 PSMA5 Homo sapiens P28066
Anti Tag CoIP
35271311
Intra PSMA4 P25789 PSMA1 Homo sapiens P25786
Pull Down
15225636
Intra PSMA4 P25789 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra PSMA4 P25789 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra PSMA4 P25789 HTT Homo sapiens P42858
Y2H Array
32814053
Intra PSMA4 P25789 PSMA2 Homo sapiens P25787
Anti Tag CoIP
35271311
Intra PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
17948026
Intra PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
14733938
Intra PSMA4 P25789 PSMA2 Homo sapiens P25787
Y2H
15225636
Intra PSMA4 P25789 PSMA7 Homo sapiens O14818
Pull Down
15225636
Intra PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H Prey Pooling
32296183
Intra PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H
14733938
Intra PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H
15225636
Intra PSMA4 P25789 PSMA7 Homo sapiens O14818
Y2H Array
32296183
Cross PSMA4 P25789 Bhlhe41 Mus musculus Q99PV5
Anti Tag CoIP
22801492
Intra PSMA4 P25789 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra PSMA4 P25789 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra PSMA4 P25789 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra PSMA4 P25789 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra PSMA4 P25789 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra PSMA4 P25789 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra PSMA4 P25789 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PSMA4 VGNC VGNC:76439
Mus musculus PSMA4 MGD MGI:1347060
Bos taurus PSMA4 VGNC VGNC:33439
Felis catus PSMA4 VGNC VGNC:80886
Rattus norvegicus PSMA4 RGD RGD:61846