AGPAT3 - 1-acylglycerol-3-phosphate O-acyltransferase 3 Gene

Homo sapiens

Also known as LPAAT3; LPLAT3; 1-AGPAT 3; LPAAT-GAMMA1

Gene ID: 56894 | Gene type: protein coding

About AGPAT3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:43,865,223-43,987,592 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues.

Summary

The protein encoded by this gene is an Acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AGPAT3 Products(5)

mRNA	Protein	Name
NM_001037553.2	NP_001032642.1	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369878.1	NP_001356807.1	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369880.1	NP_001356809.1	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1
NM_001369881.1	NP_001356810.1	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2
NM_020132.5	NP_064517.1	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	21173190	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21173190	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	21173190	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT3 Protein Structure

Acyltransferase

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1-AGP acyltransferase 3

Related Diseases

Diseases

Alias

Complete Generalized Lipodystrophy

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00458	AGPAT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGPAT3	RGD	RGD:1305787
Canis familiaris	AGPAT3	VGNC	VGNC:37712
Felis catus	AGPAT3	VGNC	VGNC:59686
Macaca mulatta	AGPAT3	VGNC	VGNC:84744
Mus musculus	AGPAT3	MGD	MGI:1336186
Bos taurus	AGPAT3	VGNC	VGNC:25736

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