PSMB10 - proteasome 20S subunit beta 10 Gene

Homo sapiens

Also known as LMP10; MECL1; PRAAS5; beta2i

Gene ID: 5699 | Gene type: protein coding

About PSMB10

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,934,506-67,936,850 (from NCBI)

This gene has 5 transcripts (splice variants), 172 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 53.2), lymph node (RPKM 48.6) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (Proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

PSMB10 Products(1)

mRNA	Protein	Name
NM_002801.4	NP_002792.1	proteasome subunit beta type-10

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14733938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB10 Protein Structure

Proteasome

Pr_beta_C

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

proteasome subunit beta type-10

low molecular mass protein 10

PSMB10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMB10	P40306	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	PSMB10	P40306	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	PSMB10	P40306	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	PSMB10	P40306	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	PSMB10	P40306	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	PSMB10	P40306	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	PSMB10	P40306	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	PSMB10	P40306	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	PSMB10	P40306	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	PSMB10	P40306	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	PSMB10	P40306	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	PSMB10	P40306	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	PSMB10	P40306	PSMB3	Homo sapiens	P49720	Y2H	14733938
Intra	PSMB10	P40306	CRX	Homo sapiens	O43186	Validated Y2H	25416956
Intra	PSMB10	P40306	CRX	Homo sapiens	O43186	Y2H Prey Pooling	25416956
Intra	PSMB10	P40306	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	PSMB10	P40306	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	PSMB10	P40306	CCNDBP1	Homo sapiens	O95273	Y2H	21516116
Intra	PSMB10	P40306	CCNDBP1	Homo sapiens	O95273	Y2H Array	31515488
Intra	PSMB10	P40306	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	PSMB10	P40306	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Proteasome-Associated Autoinflammatory Syndrome 5

PRAAS5

Proteasome-Associated Autoinflammatory Syndrome

Aldd Syndrome	Autoinflammation-Lipodystrophy-Dermatosis Syndrome
Praas	Proteasome Disability Syndrome

Immunodeficiency 12

Combined Immunodeficiency Due To Malt1 Deficiency	IMD12
Immunodeficiency, Type 12

Hypertensive Retinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11300	PSMB10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMB10	VGNC	VGNC:97570
Canis familiaris	PSMB10	VGNC	VGNC:57370
Mus musculus	PSMB10	MGD	MGI:1096380
Rattus norvegicus	PSMB10	RGD	RGD:1307428
Bos taurus	PSMB10	VGNC	VGNC:97305

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