PSMB3 - proteasome 20S subunit beta 3 Gene

Homo sapiens

Also known as HC10-II

Gene ID: 5691 | Gene type: protein coding

About PSMB3

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,752,741-38,764,225 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 234 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 52.0), lymph node (RPKM 51.4) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S Proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

PSMB3 Products(1)

mRNA	Protein	Name
NM_002795.4	NP_002786.2	proteasome subunit beta type-3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14733938	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB3 Protein Structure

Proteasome

0
100
205 a.a.

Protein Preferred Names

Protein Names

proteasome subunit beta type-3

epididymis secretory sperm binding protein

PSMB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMB3	P49720	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	PSMB3	P49720	CRACR2B	Homo sapiens	Q8N4Y2-3	Validated Y2H	32296183
Intra	PSMB3	P49720	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	PSMB3	P49720	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Intra	PSMB3	P49720	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMB5	Homo sapiens	P28074	Y2H	17948026
Intra	PSMB3	P49720	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	PSMB2	Homo sapiens	P49721	Y2H	14733938
Intra	PSMB3	P49720	PSMB2	Homo sapiens	P49721	Anti Tag CoIP	35271311
Intra	PSMB3	P49720	PSMB2	Homo sapiens	P49721	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMB3	P49720	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311
Intra	PSMB3	P49720	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	35271311
Intra	PSMB3	P49720	PSMB10	Homo sapiens	P40306	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	PSMB10	Homo sapiens	P40306	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	PSMB10	Homo sapiens	P40306	Y2H	14733938
Intra	PSMB3	P49720	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	33961781
Intra	PSMB3	P49720	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	28514442
Intra	PSMB3	P49720	POMP	Homo sapiens	Q9Y244	Y2H	17948026
Intra	PSMB3	P49720	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	35271311
Intra	PSMB3	P49720	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	PSMB3	P49720	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	PSMB3	P49720	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	PSMB3	P49720	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nodular Episcleritis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11303	PSMB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMB3	VGNC	VGNC:99213
Felis catus	PSMB3	VGNC	VGNC:97571
Rattus norvegicus	PSMB3	RGD	RGD:61875
Mus musculus	PSMB3	MGD	MGI:1347014
Bos taurus	PSMB3	VGNC	VGNC:33447

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