2. Gene
  3. PLSCR3 - phospholipid scramblase 3 Gene

PLSCR3 - phospholipid scramblase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57048 | Gene type: protein coding

About PLSCR3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,389,727-7,394,525 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 407 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 12.9), fat (RPKM 12.1) and 25 other tissues.

Summary

Enables several functions, including calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including cardiolipin biosynthetic process; regulation of apoptotic process; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLSCR3 Products(6)

mRNA Protein Name
NM_001201576.2 NP_001188505.1 phospholipid scramblase 3 isoform 1
NM_001369407.1 NP_001356336.1 phospholipid scramblase 3 isoform 1
NM_001369420.1 NP_001356349.1 phospholipid scramblase 3 isoform 2
NM_001369421.1 NP_001356350.1 phospholipid scramblase 3 isoform 3
NM_001369422.1 NP_001356351.1 phospholipid scramblase 3 isoform 3
NM_020360.4 NP_065093.2 phospholipid scramblase 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
18358005 GOA
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
18256029 GOA
enables lead ion binding IMP
IMP: Inferred from mutant phenotype
31769662 GOA
enables magnesium ion binding IMP
IMP: Inferred from mutant phenotype
29337693 GOA
enables mercury ion binding IMP
IMP: Inferred from mutant phenotype
31769662 GOA
enables phospholipid scramblase activity IMP
IMP: Inferred from mutant phenotype
14573790 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12649167 GOA
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
12649167 GOA
involved in cardiolipin biosynthetic process IMP
IMP: Inferred from mutant phenotype
16939411 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
14573790 GOA
involved in regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
14573790 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
12649167 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
12649167 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19333378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLSCR3 Protein Structure

Scramblase

Scramblase: Scramblase (64 - 284)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

phospholipid scramblase 3

PL scramblase 3

PLSCR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLSCR3 Q9NRY6 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 LCE4A Homo sapiens Q5TA78
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 LCE2B Homo sapiens O14633
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 LCE2B Homo sapiens O14633
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP15-1 Homo sapiens Q3LI76
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 KRTAP15-1 Homo sapiens Q3LI76
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 S100A7L2 Homo sapiens Q5SY68
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 S100A7L2 Homo sapiens Q5SY68
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
PLSCR3 Q9NRY6 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
Intra
PLSCR3 Q9NRY6 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 AIPL1 Homo sapiens Q9NZN9
Validated Y2H
32296183
Intra
PLSCR3 Q9NRY6 C22orf39 Homo sapiens Q6P5X5
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 C22orf39 Homo sapiens Q6P5X5
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
25416956
Intra
PLSCR3 Q9NRY6 CATSPER1 Homo sapiens Q8NEC5
Y2H Array
25416956
Intra
PLSCR3 Q9NRY6 CATSPER1 Homo sapiens Q8NEC5
Y2H Prey Pooling
25416956
Intra
PLSCR3 Q9NRY6 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
PLSCR3 Q9NRY6 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
PLSCR3 Q9NRY6 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
PLSCR3 Q9NRY6 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Barth Syndrome

3-Methylglutaconic Aciduria Type 2

BTHS

Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

Mga Type Ii

Mga2

Mgca2

Mga Type 2

3-Methylglutaconic Aciduria Type Ii

3-Methylglutaconic Aciduria, Type Ii

Mga, Type Ii

3-Methylglutaconicaciduria Type 2

3-Methylglutaconicaciduria Type Ii

Taz Defect

3 Methylglutaconic Aciduria, Type Ii

Dnajc19 Defect

Cardioskeletal Myopathy-Neutropenia Syndrome

X-Linked Cardioskeletal Myopathy And Neutropenia

3-Alpha-Methylglutaconic Aciduria Type 2

Agm2

Cardioskeletal Myopathy-Neutropenia

Invm

Left Ventricular Non-Compaction Isolated X-Linked

Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

Agammaglobulinemia 2, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10742 PLSCR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLSCR3 MGD MGI:1917560
Felis catus PLSCR3 VGNC VGNC:64247
Bos taurus PLSCR3 VGNC VGNC:55863
Rattus norvegicus PLSCR3 RGD RGD:1307016
Macaca mulatta PLSCR3 VGNC VGNC:76035
Canis familiaris PLSCR3 VGNC VGNC:56014