PLSCR3 - phospholipid scramblase 3 Gene

Homo sapiens

Gene ID: 57048 | Gene type: protein coding

About PLSCR3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,389,727-7,394,525 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 407 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 12.9), fat (RPKM 12.1) and 25 other tissues.

Summary

Enables several functions, including calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including cardiolipin biosynthetic process; regulation of apoptotic process; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLSCR3 Products(6)

mRNA	Protein	Name
NM_001201576.2	NP_001188505.1	phospholipid scramblase 3 isoform 1
NM_001369407.1	NP_001356336.1	phospholipid scramblase 3 isoform 1
NM_001369420.1	NP_001356349.1	phospholipid scramblase 3 isoform 2
NM_001369421.1	NP_001356350.1	phospholipid scramblase 3 isoform 3
NM_001369422.1	NP_001356351.1	phospholipid scramblase 3 isoform 3
NM_020360.4	NP_065093.2	phospholipid scramblase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	18358005	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	18256029	GOA
enables lead ion binding	IMP IMP: Inferred from mutant phenotype	31769662	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	29337693	GOA
enables mercury ion binding	IMP IMP: Inferred from mutant phenotype	31769662	GOA
enables phospholipid scramblase activity	IMP IMP: Inferred from mutant phenotype	14573790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12649167	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	12649167	GOA
involved in cardiolipin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16939411	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	14573790	GOA
involved in regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	14573790	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	12649167	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12649167	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19333378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLSCR3 Protein Structure

Scramblase

0
100
200
295 a.a.

Protein Preferred Names

Protein Names

phospholipid scramblase 3

PL scramblase 3

Related Diseases

Diseases

Alias

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10742	PLSCR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLSCR3	MGD	MGI:1917560
Felis catus	PLSCR3	VGNC	VGNC:64247
Bos taurus	PLSCR3	VGNC	VGNC:55863
Rattus norvegicus	PLSCR3	RGD	RGD:1307016
Macaca mulatta	PLSCR3	VGNC	VGNC:76035
Canis familiaris	PLSCR3	VGNC	VGNC:56014

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