PELI1 - pellino E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Gene ID: 57162 | Gene type: protein coding

About PELI1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:64,092,652-64,144,420 (from NCBI)

This gene has 4 transcripts (splice variants), 279 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 57.0), esophagus (RPKM 14.7) and 19 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Involved in several processes, including negative regulation of necroptotic process; protein polyubiquitination; and response to lipopolysaccharide. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PELI1 Products(1)

mRNA	Protein	Name
NM_020651.4	NP_065702.2	E3 ubiquitin-protein ligase pellino homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12496252	GOA
enables ubiquitin protein ligase activity	EXP EXP: Inferred from Experiment	29883609	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	29883609	GOA
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	30952868	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	33215753	GOA
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	29883609	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	30952868	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29883609	GOA
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	29883609	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	30952868	GOA
involved in protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	29883609	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19193853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in site of double-strand break	IDA IDA: Inferred from direct assay	30952868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELI1 Protein Structure

Pellino

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase pellino homolog 1

RING-type E3 ubiquitin transferase pellino homolog 1

PELI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PELI1	Q96FA3	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	PELI1	Q96FA3	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	PELI1	Q96FA3	PDAP1	Homo sapiens	Q13442	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	PDAP1	Homo sapiens	Q13442	Y2H Array	32296183
Intra	PELI1	Q96FA3	VAC14	Homo sapiens	Q08AM6	Validated Y2H	25416956
Intra	PELI1	Q96FA3	TP63	Homo sapiens	Q9H3D4	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	TP63	Homo sapiens	Q9H3D4	Validated Y2H	32296183
Intra	PELI1	Q96FA3	TP63	Homo sapiens	Q9H3D4	Y2H Array	32296183
Intra	PELI1	Q96FA3	LMNA	Homo sapiens	P02545	Y2H Array	32296183
Intra	PELI1	Q96FA3	LMNA	Homo sapiens	P02545	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	IRAK1	Homo sapiens	P51617	Anti Bait CoIP	12496252
Intra	PELI1	Q96FA3	IRAK1	Homo sapiens	P51617	Protein Kinase Assay	19264966
Intra	PELI1	Q96FA3	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	12496252
Intra	PELI1	Q96FA3	IRAK1	Homo sapiens	P51617	Anti Bait CoIP	16884718
Intra	PELI1	Q96FA3	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	PELI1	Q96FA3	IRAK4	Homo sapiens	Q9NWZ3	Anti Bait CoIP	12496252
Intra	PELI1	Q96FA3	IRAK4	Homo sapiens	Q9NWZ3	Protein Kinase Assay	19264966
Intra	PELI1	Q96FA3	IRAK4	Homo sapiens	Q9NWZ3	Validated Y2H	32296183
Intra	PELI1	Q96FA3	IRAK4	Homo sapiens	Q9NWZ3	Anti Tag CoIP	12496252
Intra	PELI1	Q96FA3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	PELI1	Q96FA3	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	PELI1	Q96FA3	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	PELI1	Q96FA3	RIMS4	Homo sapiens	Q9H426	Validated Y2H	32296183
Intra	PELI1	Q96FA3	RIMS4	Homo sapiens	Q9H426	Y2H Array	32296183
Intra	PELI1	Q96FA3	RIMS4	Homo sapiens	Q9H426	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	PELI1	Q96FA3	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	PELI1	Q96FA3	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	PELI1	Q96FA3	CNTROB	Homo sapiens	Q8N137	Y2H Array	32296183
Intra	PELI1	Q96FA3	CNTROB	Homo sapiens	Q8N137	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PELI1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75970	Pellino-1 Protein, Human (sf9, His-GST)	Q96FA3 (M1-D418)	≥95%

Related Diseases

Diseases

Alias

Tyrosinemia, Type Iii

Tyrosinemia Type Iii	4-Hydroxyphenylpyruvate Dioxygenase Deficiency
TYRSN3	4-Hydroxyphenylpyruvic Acid Oxidase Deficiency
Tyrosinemia Type 3	4-Alpha Hydroxyphenylpyruvate Dioxygenase Deficiency
4-Alpha Hydroxyphenylpyruvic Acid Oxidase Deficiency	Tyrosinemia Due To 4-Hydroxyphenylpyruvate Dioxygenase Deficiency
Tyrosinemia Due To 4-Hydroxyphenylpyruvic Acid Oxidase Deficiency	Tyrosinemia Due To Hpd Deficiency
Tyrosinemia 3

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157435	PELI1-IN-1	Inhibitor	98.14%	Unkown
HY-RS10320	PELI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PELI1	VGNC	VGNC:68783
Macaca mulatta	PELI1	VGNC	VGNC:106195
Mus musculus	PELI1	MGD	MGI:1914495
Bos taurus	PELI1	VGNC	VGNC:32740
Canis familiaris	PELI1	VGNC	VGNC:44414
Rattus norvegicus	PELI1	RGD	RGD:1311199
Others	PELI1	NCBI

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