Ccr1 - C-C motif chemokine receptor 1 Gene

Rattus norvegicus

Gene ID: 57301 | Gene type: protein coding

About Ccr1

Biased expression in Lung (RPKM 74.6), Spleen (RPKM 54.4) and 9 other tissues.

Summary

Enables C-C chemokine binding activity. Involved in cerebellum development and inflammatory response. Located in external side of plasma membrane and neuronal cell body. Used to study colitis. Biomarker of anterior uveitis. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ccr1 Products(1)

mRNA	Protein	Name
NM_020542.2	NP_065417.1	C-C chemokine receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-C chemokine binding	IDA IDA: Inferred from direct assay	11091494	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	12541321	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	15764707	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr1 Protein Structure

7tmA_CCR1

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 1

chemokine (C-C motif) receptor 1

macrophage inflammatory protein-1 alpha receptor

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	99.47%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12080	BX471	Antagonist	99.94%	Unkown
HY-18611	RS102895 hydrochloride	Antagonist	99.87%	Unkown
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-18611A	RS102895	Antagonist	99.97%	Unkown
HY-124759	CCR1 antagonist 9	Antagonist	99.93%	Unkown
HY-103355	YM022	Antagonist	99.93%	Unkown
HY-15546	BMS-817399	Antagonist	99.83%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-12079	CP-481715	Antagonist	/	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown
HY-124668	CCR1 antagonist 12	Antagonist	/	Unkown
HY-P4191A	Met-RANTES (human) (acetate)	Antagonist	99.62%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr1	NCBI	NCBI:1230

Name
Email *

	Sorry, but the email address you supplied was invalid.