CCR1 - C-C motif chemokine receptor 1 Gene

Homo sapiens

Also known as CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1

Gene ID: 1230 | Gene type: protein coding

About CCR1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,201,711-46,208,313 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues.

Summary

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and Parasite. This gene and other Chemokine Receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

CCR1 Products(1)

mRNA	Protein	Name
NM_001295.3	NP_001286.1	C-C chemokine receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-C chemokine binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	10734056	GOA
enables chemokine (C-C motif) ligand 5 binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables chemokine (C-C motif) ligand 7 binding	IPI IPI: Inferred from physical interaction	7545673	GOA
enables chemokine receptor activity	IDA IDA: Inferred from direct assay	10660125	GOA
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	10734056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8699119	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10734056	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	10734056	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	21403648	GOA
involved in exocytosis	IDA IDA: Inferred from direct assay	10734056	GOA
involved in immune response	IDA IDA: Inferred from direct assay	10734056	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	10734056	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	29930254	GOA
involved in negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21403648	GOA
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	15764707	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24056371	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10734056	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18587271	GOA
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21403648	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	10706735	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10660125	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15001559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR1 Protein Structure

7tm_1

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 1

C-C CKR-1	CC-CKR-1
CCR-1	LD78 receptor
MIP-1alpha-R	RANTES receptor
RANTES-R	chemokine (C-C motif) receptor 1
macrophage inflammatory protein 1-alpha receptor

CCR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Prey Pooling	32296183
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Validated Y2H	32296183
Intra	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Array	32296183
Intra	CCR1	P32246	CCL5	Homo sapiens	P13501	FACS	28381538
Intra	CCR1	P32246	PLP2	Homo sapiens	Q04941	Imaging	15474493
Intra	CCR1	P32246	PLP2	Homo sapiens	Q04941	Anti Tag CoIP	33961781
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Anti Tag CoIP	15001559
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	IF	15001559
Intra	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Y2H	15001559

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Corneal Ulcer

Cornea Ulcer	Ulcerative Keratitis
Corneal Ulcer Nos

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	99.47%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12080	BX471	Antagonist	99.94%	Unkown
HY-18611	RS102895 hydrochloride	Antagonist	99.87%	Unkown
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	Unkown
HY-103360	J-113863	Antagonist	≥99.0%	Unkown
HY-18611A	RS102895	Antagonist	99.97%	Unkown
HY-124759	CCR1 antagonist 9	Antagonist	99.93%	Unkown
HY-103355	YM022	Antagonist	99.93%	Unkown
HY-15546	BMS-817399	Antagonist	99.83%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-12079	CP-481715	Antagonist	/	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown
HY-124668	CCR1 antagonist 12	Antagonist	/	Unkown
HY-P4191A	Met-RANTES (human) (acetate)	Antagonist	99.62%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CCR1	VGNC	VGNC:102023
Rattus norvegicus	CCR1	RGD	RGD:708446
Mus musculus	CCR1	MGD	MGI:104618
Macaca mulatta	CCR1	VGNC	VGNC:70737
Others	CCR1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.