WDR18 - WD repeat domain 18 Gene

Homo sapiens

Also known as Ipi3; R32184_1

Gene ID: 57418 | Gene type: protein coding

About WDR18

This gene has 11 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in kidney (RPKM 9.8), colon (RPKM 5.8) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

WDR18 Products(3)

mRNA	Protein	Name
NM_001372085.1	NP_001359014.1	WD repeat-containing protein 18 isoform 1
NM_001372086.1	NP_001359015.1	WD repeat-containing protein 18 isoform 2
NM_024100.4	NP_077005.2	WD repeat-containing protein 18 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21326211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR18 Protein Structure

WD40

0
100
189 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 18

Involved in Processing ITS2 3 homolog

WDR18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR18	Q9BV38	TEX10	Homo sapiens	Q9NXF1	Anti Tag CoIP	33961781
Intra	WDR18	Q9BV38	TEX10	Homo sapiens	Q9NXF1	Anti Tag CoIP	28514442
Intra	WDR18	Q9BV38	SENP3	Homo sapiens	Q9H4L4	Anti Tag CoIP	21326211
Intra	WDR18	Q9BV38	SENP3	Homo sapiens	Q9H4L4	Anti Tag CoIP	33961781
Intra	WDR18	Q9BV38	SENP3	Homo sapiens	Q9H4L4	Anti Tag CoIP	28514442
Intra	WDR18	Q9BV38	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	33961781
Intra	WDR18	Q9BV38	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	28514442
Intra	WDR18	Q9BV38	PELP1	Homo sapiens	Q8IZL8	Anti Bait CoIP	36351913
Intra	WDR18	Q9BV38	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	21326211
Intra	WDR18	Q9BV38	PELP1	Homo sapiens	Q8IZL8	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15765	WDR18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WDR18	VGNC	VGNC:36885
Canis familiaris	WDR18	VGNC	VGNC:48354
Mus musculus	WDR18	MGD	MGI:2158400
Rattus norvegicus	WDR18	RGD	RGD:1310646
Macaca mulatta	WDR18	VGNC	VGNC:79103
Felis catus	WDR18	VGNC	VGNC:67018

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