SENP3 - SUMO specific peptidase 3 Gene

Homo sapiens

Also known as SSP3; Ulp1; SMT3IP1

Gene ID: 26168 | Gene type: protein coding

About SENP3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,561,919-7,571,969 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 20.2), brain (RPKM 14.1) and 25 other tissues.

Summary

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

SENP3 Products(1)

mRNA	Protein	Name
NM_015670.6	NP_056485.2	sentrin-specific protease 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	32832608	GOA
enables deSUMOylase activity	IDA IDA: Inferred from direct assay	36050397	GOA
enables deSUMOylase activity	IMP IMP: Inferred from mutant phenotype	27814492	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18259216	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	32832608	GOA
involved in protein desumoylation	IDA IDA: Inferred from direct assay	32832608	GOA
involved in protein desumoylation	IMP IMP: Inferred from mutant phenotype	27814492	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP3 Protein Structure

Peptidase_C48

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

sentrin-specific protease 3

SUMO-1-specific protease 3

SENP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SENP3	Q9H4L4	TEX10	Homo sapiens	Q9NXF1	Pull Down	21326211
Intra	SENP3	Q9H4L4	TEX10	Homo sapiens	Q9NXF1	Anti Tag CoIP	33961781
Intra	SENP3	Q9H4L4	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	19680224
Intra	SENP3	Q9H4L4	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	SENP3	Q9H4L4	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	SENP3	Q9H4L4	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	SENP3	Q9H4L4	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	21326211
Intra	SENP3	Q9H4L4	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	33961781
Intra	SENP3	Q9H4L4	PELP1	Homo sapiens	Q8IZL8	Pull Down	21326211
Intra	SENP3	Q9H4L4	PELP1	Homo sapiens	Q8IZL8	Anti Bait CoIP	21326211
Intra	SENP3	Q9H4L4	WDR18	Homo sapiens	Q9BV38	Anti Tag CoIP	33961781
Intra	SENP3	Q9H4L4	WDR18	Homo sapiens	Q9BV38	Anti Tag CoIP	21326211
Intra	SENP3	Q9H4L4	WDR18	Homo sapiens	Q9BV38	Pull Down	21326211
Intra	SENP3	Q9H4L4	NPM1	Homo sapiens	P06748	IF	18259216
Intra	SENP3	Q9H4L4	NPM1	Homo sapiens	P06748	Anti Tag CoIP	18259216
Intra	SENP3	Q9H4L4	NPM1	Homo sapiens	P06748	Pull Down	21326211

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12673	SENP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SENP3	MGD	MGI:2158736
Rattus norvegicus	SENP3	RGD	RGD:1312040
Others	SENP3	NCBI

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