PELP1 - proline, glutamate and leucine rich protein 1 Gene

Homo sapiens

Also known as MNAR; P160

Gene ID: 27043 | Gene type: protein coding

About PELP1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,669,774-4,704,137 (from NCBI)

This gene has 15 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a transcription factor which coactivates transcription of Estrogen Receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the Estrogen Receptor family. This gene may be involved in the progression of several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

PELP1 Products(2)

mRNA	Protein	Name
NM_001278241.2	NP_001265170.1	proline-, glutamic acid- and leucine-rich protein 1 isoform 2
NM_014389.3	NP_055204.4	proline-, glutamic acid- and leucine-rich protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IMP IMP: Inferred from mutant phenotype	27814492	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	17505058	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	17505058	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17505058	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	17505058	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27814492	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELP1 Protein Structure

RIX1

NUC202

0
200
400
600
800
1000
1130 a.a.

Protein Preferred Names

Protein Names

proline-, glutamic acid- and leucine-rich protein 1

modulator of non-genomic activity of estrogen receptor

Related Diseases

Diseases

Alias

Brain Oligodendroglioma

Oligodendroglioma Of Brain

Brain Ependymoma

Ependymal Tumor Of Brain

Ependymoma Of Brain

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Teeth Hard Tissue Disease

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10324	PELP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-159613	PELP1-IN-1	Inducer	/	Unkown
HY-169903	SMIP34	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PELP1	VGNC	VGNC:64111
Mus musculus	PELP1	MGD	MGI:1922523
Macaca mulatta	PELP1	VGNC	VGNC:75894
Rattus norvegicus	PELP1	RGD	RGD:1306320
Canis familiaris	PELP1	VGNC	VGNC:44417
Bos taurus	PELP1	VGNC	VGNC:32744

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