2. Gene
  3. PELP1 - proline, glutamate and leucine rich protein 1 Gene

PELP1 - proline, glutamate and leucine rich protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MNAR; P160

Gene ID: 27043 | Gene type: protein coding

About PELP1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,669,774-4,704,137 (from NCBI)

This gene has 15 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a transcription factor which coactivates transcription of Estrogen Receptor responsive genes and corepresses genes activated by Other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the Estrogen Receptor family. This gene may be involved in the progression of several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

PELP1 Products(2)

mRNA Protein Name
NM_001278241.2 NP_001265170.1 proline-, glutamic acid- and leucine-rich protein 1 isoform 2
NM_014389.3 NP_055204.4 proline-, glutamic acid- and leucine-rich protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SUMO binding IMP
IMP: Inferred from mutant phenotype
27814492 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
17505058 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
17505058 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17505058 GOA
Cellular Component GO Annotation Evidence Reference Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
17505058 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27814492 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELP1 Protein Structure

RIX1

RIX1: rRNA processing/ribosome biogenesis (73 - 224)

NUC202

NUC202: NUC202 domain (423 - 488)

NUC202

NUC202: NUC202 domain (569 - 639)

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  • 1130 a.a.
Protein Preferred Names Protein Names

proline-, glutamic acid- and leucine-rich protein 1

modulator of non-genomic activity of estrogen receptor

PELP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PELP1 Q8IZL8 MDN1 Homo sapiens Q9NU22
Anti Tag CoIP
21326211
Intra
PELP1 Q8IZL8 MDN1 Homo sapiens Q9NU22
Pull Down
21326211
Intra
PELP1 Q8IZL8 H3-3A Homo sapiens P84243
Anti Bait CoIP
20448663
Intra
PELP1 Q8IZL8 H3-3A Homo sapiens P84243
Pull Down
20448663
Intra
PELP1 Q8IZL8 TEX10 Homo sapiens Q9NXF1
Crosslink
36351913
Intra
PELP1 Q8IZL8 TEX10 Homo sapiens Q9NXF1
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
IF
21326211
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
Crosslink
36351913
Intra
PELP1 Q8IZL8 NFKB1 Homo sapiens P19838
TAP
20195357
Intra
PELP1 Q8IZL8 NFKB1 Homo sapiens P19838
Display Tech
20195357
Intra
PELP1 Q8IZL8 SUMO2 Homo sapiens P61956
Y2H Pooling
16169070
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Pull Down
20448663
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Anti Bait CoIP
20448663
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Anti Tag CoIP
20448663
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Tag CoIP
21326211
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
3D-EM
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Bait CoIP
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Bait CoIP
21326211
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Crosslink
36351913
Intra
PELP1 Q8IZL8 NPM1 Homo sapiens P06748
Anti Bait CoIP
21326211
Cross: Cross-species interaction Intra: Intraspecies interaction

PELP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83217 PELP1 Antibody (YA2962) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Brain Oligodendroglioma

Oligodendroglioma Of Brain
Brain Ependymoma

Ependymal Tumor Of Brain

Ependymoma Of Brain
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10324 PELP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-159613 PELP1-IN-1 Inducer 98.99% Unkown
HY-169903 SMIP34 Inducer ≥90.0% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PELP1 VGNC VGNC:64111
Mus musculus PELP1 MGD MGI:1922523
Macaca mulatta PELP1 VGNC VGNC:75894
Rattus norvegicus PELP1 RGD RGD:1306320
Canis familiaris PELP1 VGNC VGNC:44417
Bos taurus PELP1 VGNC VGNC:32744